Genetic variation and human disease : principles and evolutionary approaches
著者
書誌事項
Genetic variation and human disease : principles and evolutionary approaches
(Cambridge studies in biological anthropology, 11)
Cambridge University Press, 1993
大学図書館所蔵 全10件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references (p. 315-343) and index
内容説明・目次
内容説明
Recent developments in molecular and computational methods have made it possible to identify the genetic basis of any biological trait, and have led to spectacular advances in the study of human disease. This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred. This book will appeal to many biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists.
目次
- Preface
- Part I. Genes and Their Expression: 1. What is a gene?
- 2. The logic of the genome
- 3. Concepts of frequency and association in populations
- 4. Genes and phenotypes in populations
- Part II. Introduction to Genetic Epidemiology: Inference from Observational Data: 5. Segregation analysis: discrete traits in families
- 6. Segregation analysis: quantitative traits in families
- 7. Linkage analysis: finding and mapping genes for qualitative traits
- 8. Linkage analysis: finding and mapping genes for quantitative traits
- Part III. Evolution: The Time Dimension in Populations: 9. Genes over time and space
- 10. Reconstructing history: the footprints of evolution
- 11. Evolution generates heterogeneity
- Part IV. Modification of the Inherited Genotype: The Time Dimension in Individuals: 12. Phenotype amplification by the environment
- 13. Infectious disease: the response to biological challenge
- 14. Variation within the inherited genotype
- 15. Cancer and ageing: a microcosm of evolution during life
- Afterwords: towards a unified general model
- Conclusion
- Notes
- References
- Index.
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