Development of hormone receptors
著者
書誌事項
Development of hormone receptors
(Experientia supplementum, v. 53)
Birkhäuser Verlag, 1987
大学図書館所蔵 全6件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes index and bibliography
内容説明・目次
目次
- Why do hormone receptors arise? An introduction.- The evolution of recognition.- Signal receivers and signal molecules.- Interrelation of hormone receptor evolution.- Conclusions.- Mechanisms of receptor-mediated transmembrane signaling.- Receptors, acceptors channels and the problem of transmembrane-signaling.- General mechanisms of transmembrane signaling.- Receptor dynamics and transmembrane signaling.- Receptor microclustering and cell activation.- Internalized receptor and cell activation.- Summary.- Insulin receptors: structure and function.- The molecular mechanism of insulin action.- The insulin receptor kinase.- Biochemical properties of the insulin receptor kinase.- Role of receptor phosphorylation in insulin action.- Structure-function relationship of the insulin receptor kinase.- Summary and conclusions.- Internalization of polypeptide hormones and receptor recycling.- Historical perspective.- Events at the cell surface (steps 1, 2 and 3).- Initial steps of endocytosis (steps 4 and 5).- Later steps of endocytosis (steps 6, 7 and 8).- Receptor recycling.- What determines the specificity of receptor-mediated endocytosis.- Biochemical features of receptor-mediated endocytosis.- Functional implications of receptor-mediated endocytosis.- Conclusions.- The nature and development of steroid hormone receptors.- Models of steroid hormone action.- Nuclear binding sites.- Development of steroid receptors: Ontogeny of estrogen receptors.- Receptor ontogeny and hormonal imprinting.- Receptor alterations during ontogenetic development.- Why is receptor adaptation necessary? An approach based on information theory.- Experimental evidence for hormonal imprinting.- Polypeptide hormones.- Imprinting by related hormones
- the disturbing effect of 'noise'.- Overlapping imprinting by steroid hormones.- Imprinting with acid type hormones.- The importance and sensitivity of imprinting.- Hormonal imprinting in cell lines.- Cell-cell transmission of hormonal imprinting.- Hormonal imprinting at enzyme level.- The mechanism of imprinting.- The four stages of the development of encoded adaptation-requiring dynamic systems in mammals.- Medicinal aspects of hormonal imprinting.- The spectal case of hormonal imprinting, the neonatal influence of sex.- Historical perspectives.- Environmental influences on sexual differentiation.- Genetic influences on sexual differentiation.- Hormonal influences on sexual differentiation.- 1. Differentiation of the gonads.- 2. Differentiation of reproductive tract and external genitalia.- 3. Differentiation of the brain.- Conclusions.- The mechanism of receptor development as implied by hormonal imprinting studies on unicellular organisms.- The role of the cell membrane in hormonal imprinting.- The role of second messengers in hormonal imprinting.- Impact of the inhibition of endocytosis, transcription and translation on hormonal imprinting.- Impact of hormone concentration and time factor on hormonal imprinting.- Which materials can induce imprinting.- Study of induced receptors in the Tetrahymena.- Receptor 'memory'Why do hormone receptors arise? An introduction.- The evolution of recognition.- Signal receivers and signal molecules.- Interrelation of hormone receptor evolution.- Conclusions.- Mechanisms of receptor-mediated transmembrane signaling.- Receptors, acceptors channels and the problem of transmembrane-signaling.- General mechanisms of transmembrane signaling.- Receptor dynamics and transmembrane signaling.- Receptor microclustering and cell activation.- Internalized receptor and cell activation.- Summary.- Insulin receptors: structure and function.- The molecular mechanism of insulin action.- The insulin receptor kinase.- Biochemical properties of the insulin receptor kinase.- Role of receptor phosphorylation in insulin action.- Structure-function relationship of the insulin receptor kinase.- Summary and conclusions.- Internalization of polypeptide hormones and receptor recycling.- Historical perspective.- Events at the cell surface (steps 1, 2 and 3).- Initial steps of endocytosis (steps 4 and 5).- Later steps of endocytosis (steps 6, 7 and 8).- Receptor recycling.- What determines the specificity of receptor-mediated endocytosis.- Biochemical features of receptor-mediated endocytosis.- Functional implications of receptor-mediated endocytosis.- Conclusions.- The nature and development of steroid hormone receptors.- Models of steroid hormone action.- Nuclear binding sites.- Development of steroid receptors: Ontogeny of estrogen receptors.- Receptor ontogeny and hormonal imprinting.- Receptor alterations during ontogenetic development.- Why is receptor adaptation necessary? An approach based on information theory.- Experimental evidence for hormonal imprinting.- Polypeptide hormones.- Imprinting by related hormones
- the disturbing effect of 'noise'.- Overlapping imprinting by steroid hormones.- Imprinting with acid type hormones.- The importance and sensitivity of imprinting.- Hormonal imprinting in cell lines.- Cell-cell transmission of hormonal imprinting.- Hormonal imprinting at enzyme level.- The mechanism of imprinting.- The four stages of the development of encoded adaptation-requiring dynamic systems in mammals.- Medicinal aspects of hormonal imprinting.- The spectal case of hormonal imprinting, the neonatal influence of sex.- Historical perspectives.- Environmental influences on sexual differentiation.- Genetic influences on sexual differentiation.- Hormonal influences on sexual differentiation.- 1. Differentiation of the gonads.- 2. Differentiation of reproductive tract and external genitalia.- 3. Differentiation of the brain.- Conclusions.- The mechanism of receptor development as implied by hormonal imprinting studies on unicellular organisms.- The role of the cell membrane in hormonal imprinting.- The role of second messengers in hormonal imprinting.- Impact of the inhibition of endocytosis, transcription and translation on hormonal imprinting.- Impact of hormone concentration and time factor on hormonal imprinting.- Which materials can induce imprinting.- Study of induced receptors in the Tetrahymena.- Receptor 'memory' in unicellular model systems.- Structural studies on membrane receptors of Tetrahymena.- Specificity of the hormone receptors of Tetrahymena.- The phylogeny of the endocrine system.- The scope of phylogeny.- Thyroidal phylogenesis.- The steroid ring system.- Peptide hormones.- Pathways of endocrine diversification.- Multiple sites and actions.- Invertebrates.- Challenging perspectives.- A new approach to the molecular evolution of hormones: the receptorial aspect.- The signal molecule potential of amino acids.- The signal molecule potential of oligopeptides.- Common origin and phylogenetic diversification of animal hormonal systems.- The significance of the evolutionary history of hormones.- The approach of comparative physiology.- The common base of intercellular messenger substances in multicellular organisms.- The different evolutions of animal and plant hormonal systems.- Diversification of hormonal systems in multicellular animals.- The evolutionary history of neurosecretion.- Neuroendocrine and epithelial endocrine glands.- Under what conditions do complicated hormonal systems evolve?.- Hormonal control of sexual differentiation.- The evolution of endocrine organs from the target tissue.- The principle of polytropic action.- Summary.- Receptors for intercellular messenger molecules in microbes: similarities to vertebrate receptors and possible implications for diseases in man.- Unicellular eukaryotes.- Prokaryotes.- Conclusion.- Development of hormone receptors: Conclusions.- Vertebrate hormones exist in invertebrates, in unicellular organisms and in plants.- Lower organisms possess receptors for vertebrate hormones.- Evolutionary aspects of hormones and receptors.- The genetic code for receptor synthesis.- Hormone-induced activation of receptor synthesis.- Hormone-induced organization of receptors.- A teleological point of view.
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