Biological effects of low level exposures to chemicals and radiation

著者

書誌事項

Biological effects of low level exposures to chemicals and radiation

editor, Edward J. Calabrese

Lewis Publishers, [1992]

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注記

Based on a workshop held April 30 and May 1, 1991 at the University of Massachusetts

Includes bibliographical references and index

内容説明・目次

内容説明

This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies.

目次

  • Hypotheses on mammalian ageing, toxicity and longevity hormesis - explication by a generalized Gompertz function
  • the role of the "stress protein response" in hormesis
  • DNA repair - as influenced by age, nutrition, and exposure to toxic substances
  • biochemical mechanisms of biphasic dose-responses relationships - role of hormesis
  • effects of low dose radiation on the immune response
  • cellular adaptation as an important response during chemical carcinogenesis
  • biostatistical approaches for modelling u-shaped dose responses curves and study design consideration in assessing the biological effects of two dose doses.

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