AIDS research reviews
著者
書誌事項
AIDS research reviews
, c1993
- v. 3
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内容説明・目次
内容説明
This volume presents research advances that provide novel strategies for developing or accelerating both preventive and therapeutic efforts against HIV. Addressing the most important long- and short-term issues, "AIDS Research Reviews: Volume 3": supplies a comprehensive analysis of two HIV viral proteins, Tat and Rev, that modulate gene expression; discusses possible strategies for attacking HIV at the transcriptional level; demonstrates the potential utility of feline immunodeficiency virus as a small-animal model for HIV pathogenesis and vaccine design; reviews models for HIV pathogenesis and suggests that HIV-induced AIDS may result from immunological consequences similar to those of graft-versus-host disease; details the fine specificity of the host immune response to HIV infection; examines the therapeutic potential of various combinations of antibodies; and focuses on the challenges of "vaccine development" related to mucosal immunity and describes new poxvirus vectors for vaccine design.
With over 1830 literature citations, figures, and tables, "AIDS Research Reviews: Volume 3" is for microbiologists and virologists; molecular and cell biologists; immunologists; hematologists; oncologists; infectious disease specialists; pharmacologists; medicinal chemists, biochemists, and biotechnologists; parasitologists; and pathologists.
目次
- Molecular biology - structural determinants of specific HIV Tat/TAR and Rev/RRE interactions, Jianshi Tao and Alan D. Frankel, genome organization and genentic variation of feline immunodeficiency virus, Marnix L. Bosch, et al, molecular mechanisms of Tat and Rev, Michael R. Green
- pathogenesis - a possible role of dendritic cells in HIV-1 replication and transmission, Erik Langhoff and William A. Haseltine, models for HIV pathogenesis, Angus G. Dalgleish, autoimmune manifestations in HIV disease - clinical and experimental aspects, Thomas F. Kresina, et al, FIV - a model for retrovirus-induced pathogenesis, Louis J. Lafrado, et al, human immunodeficiency infection in Tanzania, J. Shao, et al
- host responses - in vitro correlates of HIV and SIV hurmoal immunity and infection enhancement, David C. Montefiori, natural immunity in HIV infection - role and mechanism of natural killer cell activity, Roberto Cauda and Luigi Ortona, fine specificity of the humoral immune response to HIV-1 gp160, Ronald Q. Warren and Ronald C. Kennedy, idiotypic and genetic expression of the anti-HIV antibody repertoire and its modulation by means of anti-idiotypes, Florence Boudet, et al
- immunotherapy - passive protection against HIV infection, Krishna K. Murthy, human and Chimpanzee monoclonal antibodies with antiviral activity against HIV-1, Shermaine A. Tilley and Abraham Pinter
- vaccine development - structure and functional basis of monoclonal antireceptor antibodies, Roberta Attanasio and Ronald C. Kennedy, functional epitopes of HIV/SIV envelope glycoproteins, Kristina Broliden and Douglas F. Nixon, mucosal immunity - challenges for HIV vaccines, Bruce D. Forrest, high-titer neutralization of multiple HIV-1 isolates by radially branched immunogens, Alan M. Walfield, et al, novel poxvirus strains as research tools and vaccine vectors, James Tartaglia, et al, novel adjuvants from Quillaja saponaria Molina, Charlotte Read Kensil, et al, toward global clontrol of AIDS - immediate and long-term needs, John C. Petricciani.
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