Preimplantation diagnosis of genetic diseases : a new technique in assisted reproduction

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書誌事項

Preimplantation diagnosis of genetic diseases : a new technique in assisted reproduction

editors, Yury Verlinsky and Anver M. Kuliev

Wiley-Liss, c1993

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Preimplantation Diagnosis of Genetic Diseases A New Technique in Assisted Reproduction Editors: Yury Verlinsky and Anver M. Kuliev For individuals with hereditary genetic disorders such as cystic fibrosis, muscular dystrophy, or hemophilia, the decision to reproduce can be a profoundly difficult and emotional problem. For specialists in reproductive medicine, this situation can raise a myriad of complex - often conflicting - ethical questions. Recently, a revolutionary approach to screening for genetic disorders has emerged, offering unique possibilities for resolving this dilemma. Preimplantation Diagnosis of Genetic Diseases: A New Technique in Assisted Reproduction details the latest procedures for detecting congenital disease in gametes prior to fertilization or in embryos fertilized in vitro prior to uteral implantation. This book covers current methods used in oocyte and preembryo sampling as well as the latest techniques in DNA and cytogenetic analysis in preimplantation development. This text presents detailed, practical information on such crucial topics as:blastomere and blastocyst biopsy for preimplanation genetic analysisoocyte retrieval and embryo transfer for in vitro fertilizationpreparation of necessary media and micromanipulation toolspolymerase chain reaction techniques for DNA analysis of polar bodies and preembryospreimplantation cytogenetic and enzymatic analysesethical issues involved in preimplantation genetic screening.Serving as both a practical manual for current methods and a reference for future research and clinical applications, Preimplantation Diagnosis of Genetic Diseases: A New Technique in Assisted Reproduction provides a complete overview of this dramatic development in reproductive medicine. This book will be of interest to specialists in fertility medicine, obstetrics and gynecology, embryology, genetics, molecular biology, and cytogenetics whose work defines this new frontier in biomedical science.

目次

  • Introduction
  • Approaches to Prevention of Genetic Diseases: The Place of Preimplantation Genetic Diagnosis in Prevention and Control of Congenital Disorders
  • Indications for and Organization of Preimplantation Genetic Diagnosis
  • Approaches to Preimplantation Genetic Diagnosis
  • Embryological and Technical Aspects of Preimplantation Genetic Diagnosis
  • DNA Analysis of Polar Bodies and Preembryos
  • Preimplantation Cytogenetic Analysis
  • Problems in Preimplantation Genetic Diagnosis and Areas f or Future Research
  • Ethical Issues
  • Conclusion.

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