From molecular biology to therapeutics
Author(s)
Bibliographic Information
From molecular biology to therapeutics
（Pharmacology and the skin, vol. 5）
Karger, 1993
Available at / 5 libraries
-
No Libraries matched.
- Remove all filters.
Note
Includes bibliographical references and index
Description and Table of Contents
Description
Recent advances in the molecular biology of the skin have helped to elucidate the pathological processes resulting in skin disorders. This timely publication brings together the latest data on the molecular events underlying dermatological diseases. New insights into such disorders as ichthyosis, epidermolysis bullosa and photoaging, as well as acute promyelocytic leukemia, are presented. The book also focuses on the role of steroids and retinoids in modulating normal and pathological epithelial differentiation. Special emphasis is given to the steroid/retinoid hormone receptor super-family and its role in pathogenesis and control of gene transcription. Finally, new approaches to therapy are explored, either by targeting a drug to a given receptor that specifically modulates gene expression and differentiation, or by using gene transfer technology to supplement the expression of a deficient gene.
Table of Contents
- Part 1 New insights into pathological processes: structural protein expression in the ichthyoses, P. Fleckman and B.A. Dale
- epidermolysis bullosa simplex, E.H. Epstein
- type VII collagen and the dystrophic forms of epidermolysis bullosa, molecular cloning, genetic linkage analysis and identification of mutations, A.M. Christiano et al
- acute promyelocytic leukemia - the retinoid paradox, H. de The et al
- photoaging - mechanisms of retinoic acid-induced improvement, S. Kang et al
- mechanisms of cell trafficking in skin and inflammatory dermatoses, C.H. Smith and J.N.W.N. Barker
- the mouse tyrosinase gene, pigment cell-specific gene expression in transgenic mice, F. Beermann et al
- the telogen follicle - a model for studying hair growth, R.M. Lavker et al. Part 2 Hormones and receptors: regulation of keratin gene expression by hormones, vitamins and growth factors, M. Blumenberg et al
- the steroid/retinoid hormone receptor super-family and retinoid response pathways, M. Pfahl
- retinoic acid-responsive element in the long control region of human papillomavirus type 18, B.A. Bernard et al
- the dioxin receptor - a ligand-activated gene regulatory protein, L. Poellinger et al
- human cellular retinoic acid-binding protein gene expression, A. Astrom et al
- synthetic retinoids - receptor selectivity and biological activity, U. Reichert et al. Part 3 Growth factors and receptors: cytokine modulation of collagen and elastin gene expression, J. Uitto et al
- growth factors and receptors in normal melanocytes and melanoma cells - a review, R. Halaban
- regulation of the GM-CSF gene in T cells and signal transduction by the GM-CSF receptor, M. Watanabe et al
- psoriatic epidermal cells release elevated levels of immunoreactive and biologically active interleukins 1 and 6 - modulation of corticosteroid treatment, R. Debets et al. Part 4 New approaches to therapy: all-trans-retinoic acid - a targeting drug for differentiation therapy in acute promyelocytic leukemia, L. Degos
- vitamin D[3] analogues in psoriasis - clinical use and mode of action, K. Kragballe
- viral vectors for in vivo gene transfer, O. Danos.
by "Nielsen BookData"
