Histamine in normal and cancer cell proliferation
Author(s)
Bibliographic Information
Histamine in normal and cancer cell proliferation
（Advances in the biosciences, v. 89）
Pergamon Press, c1993
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Description and Table of Contents
Description
This volume in the series "Advances in the Biosciences" provides a review of the role of histamine in normal and cancer cell proliferation and summarizes the research carried out in this field over the last 40 years. Regarding the involvement of histamine in normal cell proliferation, the book describes, for the first time, its role in intestinal adaptation after massive bowel resection. The reader will find a definition of a new histamine receptor which explains the role of intracellular histamine in cancer development. Furthermore, this work deals with the recently recognized condition of histamine producing endocrine tumours. A chapter is devoted to the clinical application of certain histamine metabolytes as tumour markers. The book also presents the latest results of several clinical studies which demonstrate the efficacy of H2-receptor antagonists as adjuvant cancer treatment as well as the clinical use of the drug - DPPE - which blocks the intracellular histamine receptors.
Table of Contents
Tumour cell growth and metastic spread: an introductory overview (D.E. Woolley). Identification of intracellular histamine receptors HIC that regulate cell proliferation (L.J. Brandes, ES. LaBella). Does histamine behave as a growth-related polyamine? (F. Sanchez-Jimenez et al.). Role of mast cells in mitogenesis and angiogenesis in normal tissue and tumour tissue (K. Norrby, D. Woolley). A new role for endogenous histamine during haematopoiesis (M. Dy et al.). Synthesis of histamine by mouse macrophages and T-lymphocytes and its immunological significance (K. Nakano et al.). Regulation of L-histidine decarboxylase synthesis in mouse neoplastic mastocytoma P-815 cells (K. Yatsunami et al.). Molecular biological aspects of human L-histadine decarboxylase (K. Yamauchi et al.). Clinical and experimental studies on histamine producing tumours (H. Ahlman et al.). Spontaneous histamine-producing gastric carcinoid of Mastomys natalensis (S. Hosada et al.). Histamine metabolism and intestinal mucosal growth. Alterations of mucosal histamine as an expression of metabolic events (J. Kusche et al.). Histadine decarboxylase in the intestinal adaptation after canine short bowel syndrome (M. Garcia-Caballero et al.). Histamine metabolism in human breast and colorectal cancer. Its effects on other host tissues (M. Garcia-Caballero et al.). Histamine as a marker for solid malignant tumours (C.M. Moriarty). Histamine regulation of tumour growth role of HI and H2 receptors (E.S. RiveraRet al.). Histamine-2 receptor antagonists as potential adjuvant treatment of malignant diseases (H.J. Nielson, Y Kikuchi). Effects of cimetidine on tumour growth and immune function (Y. Kikuchi et al.). Effects of toremiene combined with cytostatics on the tumour growth rate and histamine concentration of human mammary cancer in mouse subrenal capsule assay (E. Suonio et al.). Results of a human pilot study testing the hypothesis that the intracellular histamine antagonist DPPE increases the therapeutic index of doxorubicin (L.J. Brandes et al.).
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