DNA and chromatin damage caused by radiation
Author(s)
Bibliographic Information
DNA and chromatin damage caused by radiation
（Advances in radiation biology / edited by Leroy G. Augenstein, Ronald Mason, Max Zelle, v. 17）
Academic Press, c1993
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Advances in Radiation Biology, Volume 17: DNA and Chromatin Damage Caused by Radiation outlines the different biological reactions to radiation. This book discusses the linear energy transfer and energy loss; DNA breaks and track structure; DNA radicals from water radicals; and radiation-induced strand breaks in isolated DNA. The radiation damage to DNA and its nearby environment; thiol radioprotectors and mechanism of action; radiolysis of water and track reactions; and computer simulation of higher order structure of DNA are also elaborated. This publication likewise covers the concept of chromatin structure; DNA supercoiling studied by sedimentation; measurement of radiation-induced DNA breakage; and analysis of damage in interphase cells. This volume is a useful reference to biologists and students concerned with DNA and chromatin damage caused by radiation.
Table of Contents
Linear Energy Transfer and Track Structure
I. Introduction
II. Linear Energy Transfer and Energy Loss
III. d-Electron Emission
IV. Condensed Phase Effects-Track Core
V. Electron Transport and the Track Halo
VI. DNA Breaks and Track Structure
VII. Summary
References
Primary Free Radical Processes in DNA
I. Introduction
II. DNA Radicals from Water Radicals-Recent Advances
III. One-Electron Oxidized Species of DNA in an Aqueous Environment
IV. Dynamics of Radiation-Induced Changes in Solid DNA
V. Radiation-Induced Strand Breaks in Isolated DNA
VI. Forward Look
References
The Chemical Consequences of Radiation Damage to DNA
I. Introduction
II. Radiation Damage to DNA and Its Nearby Environment: Direct and Quasi-direct Effects
III. The Indirect Effect
IV. The Confluence of Chemical Events for the Direct, Quasidirect, and Indirect Effects
V. Thiol Radioprotectors and Mechanism of Action
VI. Conclusions and Directions for Future Efforts
References
Computer Simulation of Initial Events in the Biochemical Mechanisms of DNA Damage
I. Introduction
II. Energy Deposition Events and Creation of Tracks by Charged Particles
III. Radiolysis of Water and Track Reactions
IV. Computer Simulation of the Biochemical Stage: The Formation of Strand Breaks
V. Results of Yields on Strand Breaks
VI. Computer Simulation of Higher Order Structure of DNA
VII. Concluding Remarks and Future Directions
References
DNA Loop Structure and Radiation Response
I. Introduction
II. The Concept of Chromatin Structure
III. DNA Supercoiling Studied by Sedimentation
IV. Alternative Methods
V. DNA Loop Structure and Growth State
VI. DNA Loop Structure, Anchoring, and Radiosensitivity
VII. Cell Cycle Effects
VIII. Conclusions
References
Radiation-Induced Damage in Chromosomal DNA Molecules: Deduction of Chromosomal DNA Organization from the Hydrodynamic Data Used to Measure DNA Double-Strand Breaks and from Stereo Electron Microscopic Observations
I. Introduction
II. Methods for the Measurement of DNA Breakage
III. DNA Size, Shape, and Number Concentration Measurement
IV. Problems Unique to the Measurement of Large DNA Molecules
V. Measurement of Radiation-Induced DNA Breakage
VI. Size and Shape Determination of Mammalian Cell Chromosomal DNA Molecules
VII. Structure of the Mammalian Chromosome
VIII. Summary
References
Ionizing Radiation Damage and Its Early Development in Chromosomes
I. Introduction
II. Chromosomal Aberrations at Mitosis
III. Analysis of Damage in Interphase Cells
IV. What Are PCC Breaks?
V. The Nature of Critical Cellular Structures
VI. Conclusions
References
Index
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