Molecular biology of DNA topoisomerases and its application to chemotherapy : proceedings of the International Symposium on DNA Topoisomerases in Chemotherapy, Nagoya, Japan, November 18-20, 1991 (ISTOP 1991)

著者

書誌事項

Molecular biology of DNA topoisomerases and its application to chemotherapy : proceedings of the International Symposium on DNA Topoisomerases in Chemotherapy, Nagoya, Japan, November 18-20, 1991 (ISTOP 1991)

edited by Toshiwo Andoh, Hideo Ikeda, Masao Oguro

CRC Press, c1993

タイトル別名

DNA topoisomerases

大学図書館所蔵 件 / 全7件

この図書・雑誌をさがす

注記

Includes bibliographical references and indexes

内容説明・目次

内容説明

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy is based on conference proceedings from the International Symposium on DNA Topoisomerases in Chemotherapy, held in Nagoya, Japan, in November 1991. The book opens with a discussion of the structural and functional properties of various types of DNA topoisomerases identified in prokaryotes and eukaryotes, in addition to their roles as cellular targets of anticancer and antimicrobial agents. Other topics addressed include the genetics and biology of DNA topoisomerases, inhibitors of microbial DNA topoisomerases and drug resistance, inhibitors of mammalian DNA topoisomerases and drug resistance, and preclinical and clinical studies of DNA topoisomerase inhibitors. Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of topoisomerases. It will be invaluable for oncologists, molecular biologists, cellular biologists, geneticists, biochemists, and pharmaceutical researchers.

目次

Organization. Preface. Tribute. DNA Topoisomerases as Targets of Therapeutics: A Structural Overview. GENETICS AND BIOLOGY OF DNA TOPOISOMERASES. DNA Gyrase: Structure, Mechanism and Interaction with Antibiotics. Purification and Characterization of DNA Topoisomerase IV in Escherichia coli. Multiple DNA Gyrase-Like Genes in Eubacteria. Involvement of Type II DNA Topoisomerases in Illegitimate Recombination in Escherichia coli: Analyses of the Partial Diploid of Phage T4 and the Specialized Transducing Particles of Phage l. Functional Dissection of DNA Topoisomerase. Cell Cycle-Dependent Phosphorylation of DNA Topoisomerase II and Modification of its Activity by Phosphorylation. Structure and Expression of the Human DNA Topoisomerase I Gene. Supercoiling Facilitates the Assembly of Active Chromatin. Techniques to Uncouple DNA Binding, Cleavage, and Religation in the Catalytic Cycles of Eukaryotic Topoisomerase I and II. Reactivity of Eukaryotic Type II Topoisomerase with Unusual DNA Structures. Differential Expression of DNA Topoisomerase II Isozymes in Developing Rat Brain. Expression of Human Type I and II DNA Topoisomerases and Their Derivatives in E.coli. INHIBITORS OF MICROBIAL DNA TOPOISOMERASES AND DRUG RESISTANCE. Quinolone Resistance Mutations in DNA Gyrase. DNA Gyrase: Mechanism and Resistance to 4-Quinolone Antibacterial Agents. Quinolone-Resistance in Pseudomonas aeruginosa. Antibacterial Activity of New Quinolones and Their Modes of Action. Molecular Mechanism of DNA Gyrase Inhibition by Quinolone Antibacterial Agents. INHIBITORS OF MAMMALIAN DNA TOPOISOMERASES AND DRUG RESISTANCE. A Novel Quinolone with Potent Activity Against Eukaryotic DNA Topoisomerase II. New Microbial Metabolites Which Induce DNA Cleavable Complex with Mammalian Topoisomerases. Mechanism of Action of Noncleavable Complex-Forming Type of Topoisomerase II Inhibitors, bis(2,6-Dioxopiperazine) Derivatives. Base Sequence Selectivity of Topoisomerase Inhibitors Suggests a Common Model for Drug Action. Mechanism of Camptothecin Resistance in Mammalian Cells: Mutation in Topoisomerase I Gene and Its Implication in Enzymatic Function. The Effects of Camptothecin on Eukaryotic Topoisomerase I. Topoisomerase Poisons that Overcome MDR1-Mediated Resistance. Drug Resistance to DNA Topoisomerase II-Targeting Agents and Development of the Reversal Agents. Phenotypic Properties of Chinese Hamster Lung Cells Resistant to DNA Topoisomerase II Inhibitors. Distribution of Topoisomerase II and Its Response to VM-26 in Drug-Sensitive and -Resistant Human Leukemic Cells. Probing Mechanisms of Cell Killing and Resistance to Anti-Topoisomerase II Agents Using Yeast. PRECLINICAL AND CLINICAL STUDIES OF DNA TOPOISOMERASE INHIBITORS. Preclinical and Clinical Development of DNA Topoisomerase I Inhibitors in the United States. In Vitro Modification of Cytocidal Effects of CPT-11 in Combination with DNA Topoisomerase II Related Agents. Phase II Study of CPT-11, a New Derivative of Camptothecin, on Leukemia and Lymphoma. Clinical Evaluation of CPT-11, a Topoisomerase I Inhibitor, in Lung Cancer. Clinical Studies of DNA Topoisomerase I Inhibitor (CPT-11) on Gynecological Cancers - Cooperative Study Group of CPT-11 on Gynecological Cancers. A Phase II Study of CPT-11, a New Camptothecin Derivative, In Patients with Metastatic Colorectal Cancer Poster Presentation. Index to Contributors.

「Nielsen BookData」 より

ページトップへ