The Molecular basis of smell and taste transduction
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Bibliographic Information
The Molecular basis of smell and taste transduction
（Ciba Foundation symposium, 179）
J. Wiley, 1993
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Hokkaido University, Library, Graduate School of Science, Faculty of Science and School of Science図書
dc20:591.1/m7322070294278
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Symposium on the Molecular Basis of Smell and Taste Transduction, held at the Ciba Foundation, London, Feb. 1993
Includes bibliographical references and index
Description and Table of Contents
Description
The Molecular Basis of Smell and Taste Transduction Chairman: Frank Margolis 1993 The survival of an organism depends largely on its ability to monitor its environment constantly and accurately. To do this, organisms have evolved a wide range of sensory systems to detect, transduce and evaluate relevant environmental signals. Smell and taste are two primary neurosensory systems that animals use to assess the external chemical environment. This monitoring is a complex operation: an organism must be capable of resolving not only a single odorant or taste stimulant from a heterogeneous mix of chemicals, but also concentration differences and their temporal variation. The systems that have developed to fulfil these tasks appear to be functionally similar in organisms as diverse as Drosophila and humans. The contemporary techniques of molecular biology, microprotein sequencing, immunohistochemistry and patch-clamp electrophysiology have permitted the study of the molecular basis of chemosensory transduction.
Consequently, characterization of the biochemical and molecular mechanisms associated with smell and taste is now experiencing an expansion that would have been unthinkable only a few years ago. Of particular interest has been the recent cloning of olfactory receptor genes: the expression patterns of some of these are described in this book. Other important work reported here includes the identification of olfactory binding proteins, genetic analysis in Drosophila and Caenorhabditis elegans, the G protein-mediated activation of second messenger pathways, and the role of ion channels, perireceptor events and mucus proteins in chemosensory transduction. The book contains contributions from many of the leading scientists working on varied aspects of the chemical senses, with discussion of their recent results and the most important questions that remain to be addressed. This book includes the latest information from this field and will be of interest to both those working on chemosensory transduction and those interested in signal transduction in general. Related Ciba Foundation Symposia: No. 160 Regeneration of vertebrate sensory cells Chairman: E. W.
Rubel 1991 ISBN 0 471 92960 3 No. 164 Interactions among cell signalling systems Chairman: Y. Nishizuka 1992 ISBN 0 471 93073 3 No. 176 The GTPase superfamily Chairman: F. McCormick 1993 ISBN 0 471 93914 5
Table of Contents
Partial table of contents: Receptor Diversity and Spatial Patterning in the Mammalian Olfactory System (L. Buck). Molecular Mechanisms of Olfactory Neuronal Gene Regulation (M. Wang & R. Reed). A New Tool for Investigating G Protein-Coupled Receptors (M. Lerner, et al.). Second Messenger Signaling in Olfaction (H. Breer). Membrane Currents and Mechanisms of Olfactory Transduction (S. Firestein & F. Zufall). Perireceptor Events in Taste (H. Schmale, et al.). Role of Apical Ion Channels in Sour Taste Transduction (S. Kinnamon). Ion Pathways in the Taste Bud and Their Significance for Transduction (J. DeSimone, et al.). Indexes.
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