The Retinoids : biology, chemistry, and medicine
著者
書誌事項
The Retinoids : biology, chemistry, and medicine
Raven Press, c1994
2nd ed
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
he Second Edition of this comprehensive reference on the retinoids reflects the important advances that have occurred since the publication of the First Edition in 1984. The contributors review current knowledge of new ligands, receptors, mechanisms of cellular action, and molecular mechanisms of control of gene expression by retinoids, and explore the impact of such discoveries on basic science and on clinical applications of retinoids. Coverage includes advances in organic synthesis and analytical chemistry of retinoids and new findings on the role of vitamin A in nutrition, the metabolism of retinol and retinoic acid, the proteins that bind retinoids, the nuclear receptors for retinoic acid, the cell biology of retinoids, and the role of retinoids in vision, embryonic development, and the immune system. A new chapter on toxicology examines the interaction of retinoids with nuclear receptor systems. The book also describes new applications of retinoids in experimental and clinical oncology and in dermatology
目次
lntroduction Michael B. Sporn and Anita B. Roberts The Synthetic Chemistry of Retinoids Marcia I. Dawson and Peter D. Hobbs Retinoid Skeletal-Bond Methodology / Methodology for Constructing the Polar Terminus of the Retinoid Skeleton Retinoids Specifically Designed to Aid Biologic Studies. Analytical Methods Harold C. Furr, Arun B. Barua, and James Allen Olson Biologic Samples / Reference Standards / Separation Methods Other Methods. Vitamin A In Human Nutrition: Public Health Considerations Barbara A. Underwood Historical Perspectives / Magnitude of the Problem of Vitamin A Deficiency Globally / Extraocular Health Consequences of Subclinical Deficiency / Assessment of Vitamin A Status. Retinol and Retinoic Acid Metabolism William S. Blaner and James Allen Olson Intestinal Uptake and Metabolism of Retinol / Hepatic Metabolism and Storage of Retinol / Uptake, Storage, and Metabolism of Retinol by Extrahepatic Tissues / Retinoic Acid Uptake and Formation / Metabolism of Retinoic Acid / Other Metabolites of Retinol. Plasma Retinol-Binding Protein Dianne Robert Soprano and William S. Blaner Retinol-Binding Protein Structure and Physiochemical Properties / The Molecular Biology of Retinol-Binding Protein / The Expression of Retinol-Binding Protein in the Liver and Extrahepatic Tissues / The Cellular Synthesis and Secretion of Retinol-Binding Protein and Its Regulation / Retinol Delivery to Cells by Retinol-Binding Protein / Clinical Studies and Possible Involvement of Retinol-Binding Protein in Disease. Cellular Retinoid-Binding Proteins David E. Ong, Marcia E. Newcomer, and Frank Chytil Discovery, Initial Characterization and Distribution of the Cellular-Retinoid Binding Proteins / Physical Properties of the Cellular-Retinoid Binding Proteins / Gene Structure and Regulation of Expression / Functions. The Retinoid Receptors David J. Mangelsdorf, Kazuhiko Umesono, and Ronald M. Evans Retinoid Receptors / A New Hormone: 9-cis-Retinoic Acid / Target-Gene Specificity / The Retinoid X Receptor Heterodimer: Master Regulator of Hormonal Signalling / Cross-Coupling in Retinoid Signalling Pathways / Retinoic Acid Receptor and Retinoid X Receptor Pattems of Expression / Human Disease. Retinoids In Photosensitive Systems John C. Saari Introduction / Overview of the Visual Process / Chromophores of Visual Pigments /photoisomerisation / Wavelength Regulation The Visual Cycle /Cellular Uptake of Retinol. Retinoids In Development Clementine Hofmann and Gregor Eichele Retinoids and Limb Development / Retinoids and the Pattern Along the Anteroposterior Body Axis / Effects of Retinoids on the Regenerating Amphibian Limb. Cellular Biology and Biochemistry of the Retinoids Lorraine J. Gudas, Michael B. Sporn, and Anita B. Roberts Overview of Mechanisms of Gene Regulation by Retinoids/ Effects of Retinoids on the Activity and Synthesis of Growth Factors and Their Receptors / Effects of Retinoids on the Activity and
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