Pharmacology of the contraceptive steroids
著者
書誌事項
Pharmacology of the contraceptive steroids
Raven Press, c1994
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注記
Includes index
内容説明・目次
内容説明
The evolution of the field of steroid contraception is traced and examined in this volume. "Pharmacology of the Contraceptive Steroids" presents a balanced synthesis of the latest knowledge on hormonal contraception, focusing on what has been learned about the ways in which such agents are developed and tested, as well as what still needs to be done to yield maximum practical compliance and non-contraceptive benefits. The book's coverage includes analyses of the pharmacokinetics and intermediate metabolism of orally administered synthetic progestins and oestrogens and of steroids administered by long-acting injections and implants; as well as comprehensive exploration of the specific pharmacodynamics of steroid agents in relation to: the hypothalamo-pituitary-ovarian axis; the mammary gland; the uterus; the adrenal cortex; the thyroid; the liver; the skeleton; the skin and muscle; the nervous system; cardiovascular function (blood pressure, coagulation, atherogenesis); metabolism of nutrients; the immune system; and teratogenesis.
It begins with a concise historical perspective on the progestins and the oestrogens, and then moves on to explain the basic mechanism of action of steroid hormones and antagonists. The next three chapters examine laboratory studies with animals, followed by an exploration in 21 chapters on pharmacological studies, focusing first on pharmacokinetics and intermediate metabolism and then pharmacodynamic studies. The book concludes with a review of interactions of contraceptive steroids with other drugs, and a consideration of statistical and epidemiological issues.
目次
- Historical perspective - the progestins, Nicola Perone, the 0estrogens, Joseph W. Goldzieher
- mechanism of action - mechanism of action of steroid hormones and antagonists, James H. Clark
- studies in laboratory animals - pharmacokinetics in various animal species, Wilhelm Kuhnz and Hartmut Blode, metabolism in animals, Frank Z. Stanczyk, issues in animal pharmacology, Richard A. Edgren
- studies in humans - pharmacokinetics and intermediate metabolism - progestins, Ken Fotherby, ethynyl oestrogens, Joseph W. Goldzieher, long-acting contraceptives, F.M. Primiero and G. Benagiano
- studies in humans - pharmacodynamics - the hypothalamo-pituitary-ovarian system, Joseph W. Goldzieher, the female breast, Fritz K. Beller, the lower reproductive tract, Elisabeth Johannison and Ivo Brosens, the adrenal gland, Steven M. Petak and Emil Steinberger, the thyroid gland, Joseph W. Goldzieher, the liver, M.H. Sillem and A.T. Teichman, bone, Morris Notelovitz, effects on the skin, Joseph W. Goldzieher, skeletal muscle function, John C. Wirth, et al, cardiovascular system - blood pressure, Robert Fraser and Ronald J. Weir, coagulation, thrombosis and contraceptive steroids - is there a link?, Fritz K. Beller, contraceptive steroids, plasma lipoprotein levels and coronary artery atherosclerosis, Scott A. Washburn, et al, metabolism - carbohydrates, Karen Elkind-Hirsch and Joseph W. Goldzieher, contraceptive steroids and plasma proteins, Goran Cullberg, vitamins and trace elements, Kosin Amatayakui, the immune system, A.H.W.M. Schuurs, et al, teratogenesis and mutagenesis, Joseph W. Goldzieher
- drug interactions - drug interactions, D.J. Back and M.L'E. Orme
- statistical and epidemiological issues - evaluating efficacy and safety, David A. Edelman and Joseph W. Goldzieher. Appendix: chemical nomenclature.
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