Modulation of differentiation by exogenous agents

Bibliographic Information

Modulation of differentiation by exogenous agents

editor Paul B. Fisher

(Mechanisms of differentiation, v. 2)

CRC Press, c1990

Other Title

Mechanisms of differentiation

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Includes bibliographical references and index

Description and Table of Contents

Description

Significant recent advances in cell culture technology now permit a detailed biochemical and molecular analysis of differentiation in both normal and tumor cells. These studies are important in attempting to understand the complex factors involved in normal growth and development, as well as the abnormalities associated with carcinogenesis. Mechanisms of Differentiation, Volumes I and II, is comprised of review chapters addressing various topics of current interest in this important area of research. Topics discussed include genes controlling differentiation, changes in gene expression during differentiation, induction of differentiation, induction of differentiation as a mode of action of chemotherapeutic agents, and the effect of cell shape, growth factors and differentiation modulating agents on the differentiated cell phenotype. Mechanisms of Differentiation is valuable to researchers involved in differentiation and development, carcinogenesis, cell biology, chemotherapy, and immunology.

Table of Contents

VOLUME II: MODULATION of DIFFERENTIATION by EXOGENOUS AGENTS Modulation of Differentiation: Potential Mechanism by Which Inferferons Induce Antitumor Activity Regulation of Tumor Antigen Expression by Recombinant Interferons Induction of Terminal Differentiation of Human Leukemic Cells by Chemotherapeutic and Cytotoxic Drugs Induced Differentiation of Transformed Cells with Polar/Apolar Compounds and the Reversibility of the Transformed Phenotype 5-Azacytidine Induction of Differentiation in Fibroblast Cells by Irradiation and Chemical Carcinogens The Early Reactions and Factors Involved in In Vitro Erythroid Differentiation of Mouse Erythroleukemia (MEL) Cells Regulation of Cell Contacts, Cell Configuration and Cytoskeletal Gene Expression in Differentiating Systems Macrophage and Granulocyte Macrophage-Colony Stimulating Factor Effects on Human Monocyte Differentiation Regulation of Phenotype by Transforming Growth Factor-b: Role of the Extracellular Matrix

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