Proteolysis and protein turnover : proceedings of the 9th ICOP Meeting, Williamsburg, Virginia, U.S.A.
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書誌事項
Proteolysis and protein turnover : proceedings of the 9th ICOP Meeting, Williamsburg, Virginia, U.S.A.
(Portland Press proceedings, v. 6)
Portland, c1993
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内容説明・目次
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ISBN 9781855780392
内容説明
The proceedings of the 9th Intemational ICOP Conference held in Williamsburg, Virginia in October 1992 discusses the latest discoveries on cellular proteases, how living cells break down proteins, how cells deten-nine which proteins are to be degraded and the role of proteases in diseases such as cancer. Scientists from a variety of disciplines discuss the regulation and mechanisms at different levels of biological organization.
目次
- Molecular aspects of proteolytic enzymes and inhibitors, A. J. Barrett
- x-ray structures of peptidases, W. Bode and W. Stoker
- multicatalytic endopeptidase, proteasome, J. Rivett
- inflammatory proteases, activation/inhibition, G. Salveson
- ATP-dependent proteases, M. Maurizi
- processing proteases, E. Kominami
- matrix/collagenases, G. Murphy
- lysosomal proteases, H. Kirschke
- cystatins and other protease inhibitors, V. Turk
- cellular aspects of proteolytic systems and mechanisms of intracellular proteolysis, M. Rechsteiner
- the ubiquitin pathway, A. Hershko
- the lysosomal pathway, F. Dice and P. Seglen
- cytosolic pathways, A. Ciechanover
- the proteasome and degradation in yeast, D. Wolf
- protein turnover in tissues/organisms, F. J. Ballard
- basic mechanisms of muscle turnover, A. Goldberg
- effects of hormones, diet, and growth factors on muscle protein breakdown, M. Goodman et al
- turnover of muscle phosphorylase - effects of muscular dystrophy, R. Beynon
- muscle turnover/growth and atrophy, A. Samarel
- protein turnover and protease gene expression in renal failure, acidosis, W. Mitch
- discussions on calpains, D. Goll
- pathological aspects of protein turnover, B. Sloane
- proteases and cancer, H. Rochefort et al
- antiproteases as therapeutic agents, H. Rubin
- proteases and tissue injury, Z. Werb and J. Travis
- proteases and HIV, H. Kido et al
- cytokines and degradation, J. Jochum
- degradation of amyloid precursor in Alzheimer's disease, C. Abraham.
- 巻冊次
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ISBN 9781855780415
内容説明
This book aims to promote a better understanding of the link between lung arterial structure and function, with the hope of ultimately improving the treatment of pulmonary hypertension. Written by scientists and clinicians who specialize in pulmonary vascular research or medicine, this book describes the changes that occur in the structure and function of the pulmonary vasclature during the development of pulmonary hypertension. Detailed information is given of the moelcular and cellular mechanism involved in this remodelling process. Topics covered include: the diversity of the pulmonary circulation and its adaption to changes in the environment; the dynamic nature of extracellular matrix metabolism; the mechanisms that regulate the remodelling process, including the roles of growth factors, vasoactive substances and mechanical forces.
目次
- Introduction, J. Reeves et al
- composition of the normal pulmonary vasculature, G. Laurent et al
- clinical aspects and pathology of pulmonary hypertension, R. Jones and L. Reid
- vascular tone, J. Evans et al
- the role of the matrix in the regulation of mass transport, P. Winlove et al
- matrix transport, P. Winlove et al
- matrix metabolism, F. Keeley et al
- phenotypic changes, K. Stenmark and R. Mecham
- the effect of mechanical forces on cell function, J. Bishop and R. Low
- the role of the endothelium in vascular remodelling, K. Dawes et al.
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