Female reproductive toxicology
著者
書誌事項
Female reproductive toxicology
(Methods in toxicology / series editors, Charles A. Tyson, Hanspeter Witschi, v. 3,
Academic Press, c1993
- : pbk
大学図書館所蔵 全7件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
内容説明・目次
- 巻冊次
-
ISBN 9780124612099
内容説明
In the tradition of Methods in Enzymology and Methods in Neurosciences, Academic Press is pleased to announce a new serial - Methods in Toxicology. There is a pressing need among researchers involved in toxicologic investigation for a series of publications that organizes and presents information on the latest experimental methodologies. To address the needs of researchers in toxicology, toxicologic pathology, pharmacology, and clinical biochemistry, this new serial provides comprehensive descriptions of state-of-the-art methods for evaluating drug and chemical toxicity. Thematic volumes focus on mechanistic approaches to the study of toxicity both in vitro and in vivo, taking advantage of the recent advances in the biological and chemical sciences that allow closer scrutiny of the mechanisms by which chemical agents cause damage. Each volume begins with an introductory chapter that offers a broad guide to the application of methods addressed in that volume. Subsequent chapters contain detailed descriptions of research protocols, accessible both to experts and those new to toxicologic investigation.
Included in each chapter are clearly defined procedures, discussions of limitations of the method, comparative considerations (species, sex, strain), interpretations of results, and explanations of how the methods may serve as alternatives to in vivo testing. Each volume of Methods in Toxicology is available in case binding for the library and Wire-O binding for the laboratory. Efforts to understand the adverse effects of reproductive toxicants must address a series of precisely timed interactions, not only among the organs involved (brain, pituitary, and ovary) but also within those organs, in the female, pregnancy may vary the primary effect, so events that occur in both the pregnant and non-pregnant animal must be assessed. This requires the use of a broad array of in vivo and in vitro techniques. This book brings together for the first time in a single volume many methods for assessing the behavioral, hormonal, and cellular changes that occur at all levels during exposure to reproductive toxicants. Each chapter contains not only a detailed, step-by-step protocol, but also the reasons for the key steps - as well as possible variations - where applicable.
For easy reference, the book is organized first by pregnancy state, then by tissue response, then by cells within that tissue. These are all tied together by an introduction that puts each method into perspective within the field and provides ways of integrating the different methods to generate a complete understanding of the effects a toxicant creates. The intent is to demystify the complexities of reproductive toxicology so that more investigators will address the area and will, in turn, produce a better understanding of the sites and modes of action of reproductive toxicants.
目次
- Use of perifusion to evaluate hormonal release in vitro and rat pituitary and hypothalamic tissue, J.M. Goldman and R.L.Cooper
- measuring sexual behavior in the female rat, R.L. Cooper et al
- monitoring of the estrous cycle in the laboratory rodent by vaginal lavage, R.L. Cooper et al
- assessment of toxicity to the ovary using follicle quantitation and morphometrics, D.R. Plowchalk et al
- ovarian target cell toxicity, B.J. Davis
- assessment of toxicant-induced alterations in the luteinizing hormone control of ovulation in the rat, J.M. Goldman and R.L. Cooper
- strategies and methods for evaluating the functional capacity of oocytes and zygotes in vitro, S.D. Perreault and S. Jeffay
- recovery and morphological evaluation of oocytes, zygotes and preimplantation embryos, S.D. Perreault and B.A. Mattson
- mouse oocytes and embryo culture, M.J. O'Brien et al
- isolation and culture of ovarian follicles from hamster mouse, and pig, G.S. Greenwald et al
- the in vitro perfused rat ovary, M. Brannstrom
- isolated perfused rabbit ovary preparation, A.M. Dharmarajan et al
- ovarian perifusion culture - a tool to assess ovarian toxicity, J.J. Peluso and A. Pappalarda
- assessment of implantation in the rat, A.M. Cummings
- pseudopregnancy and the decidual cell response in the rat, A.M. Cummings
- perfusion of the placenta, R. Miller
- trophoblast culture, R. Miller
- in vitro exposure of preimplantation embryos to potential toxicants with subsequent embryo transfer and evaluation, N.L. Bossert
- isolation and culture of rat granulosa cell cultures, K.A. Treinen
- human granulosa and granulosa luteal cell in culture, D.A. Magoffin
- porcine granulosa and theca cell culture - bioassay applications for factors modulating cell proliferation and differentiation, J.V. May
- rat thecal-interstitial cells in culture, D.A. Magoffin
- human theca interna cells in long-term culture, J.M. McAllister and E.R. Simpson
- dispersion, separation, and culture of the different cell populations of the rat, corpus luteum, S. Nelson and G. Gibori
- isolation and culture of fully differentiated bovine luteal cells, J.L. Pate
- isolation and culture of mouse uterine, epithelial and stroma cells, K.A. Ross et al.
- 巻冊次
-
: pbk ISBN 9780124612105
内容説明
Efforts to understand the adverse effects of reproductive toxicants must address a series of precisely times interactions, not only among the organs involved (brain, pituitary, and ovary) but also within those organs in the female, pregnancy may vary the primary effect, so events that occur in both the pregnant and non-pregnant animal must be assessed. This requires the use of a broad array of in vivo and in vitro techniques. This book brings together for the first time in a single volume many methods for assessing the behavioral, hormonal, and cellular changes that occur at all levels during exposure to reproductive toxicants. Each chapter contains not only a detailed, step-by-step protocol, but also the reasons for the key steps - as well as possible variations - where applicable. For easy reference, the book is organized first by pregnancy state, then by tissue response, then by cells within that tissue. These are all tied together by an introduction that puts each method into perspective within the field and provides ways of integrating the different methods to generate a complete understanding of the effects a toxicant create.
The intent is to demystify the complexities of reproductive toxicology so that more investigators will address the area and will, in turn, produce a better understanding of the sites and modes of action of reproductive toxicants.
目次
- Use of perifusion to evaluate hormonal release in vitro and rat pituitary and hypothalamic tissue, J.M. Goldman and R.L.Cooper
- measuring sexual behavior in the female rat, R.L. Cooper et al
- monitoring of the estrous cycle in the laboratory rodent by vaginal lavage, R.L. Cooper et al
- assessment of toxicity to the ovary using follicle quantitation and morphometrics, D.R. Plowchalk et al
- ovarian target cell toxicity, B.J. Davis
- assessment of toxicant-induced alterations in the luteinizing hormone control of ovulation in the rat, J.M. Goldman and R.L. Cooper
- strategies and methods for evaluating the functional capacity of oocytes and zygotes in vitro, S.D. Perreault and S. Jeffay
- recovery and morphological evaluation of oocytes, zygotes and preimplantation embryos, S.D. Perreault and B.A. Mattson
- mouse oocytes and embryo culture, M.J. O'Brien et al
- isolation and culture of ovarian follicles from hamster mouse, and pig, G.S. Greenwald et al
- the in vitro perfused rat ovary, M. Brannstrom
- isolated perfused rabbit ovary preparation, A.M. Dharmarajan et al
- ovarian perifusion culture - a tool to assess ovarian toxicity, J.J. Peluso and A. Pappalarda
- assessment of implantation in the rat, A.M. Cummings
- pseudopregnancy and the decidual cell response in the rat, A.M. Cummings
- perfusion of the placenta, R. Miller
- trophoblast culture, R. Miller
- in vitro exposure of preimplantation embryos to potential toxicants with subsequent embryo transfer and evaluation, N.L. Bossert
- isolation and culture of rat granulosa cell cultures, K.A. Treinen
- human granulosa and granulosa luteal cell in culture, D.A. Magoffin
- porcine granulosa and theca cell culture - bioassay applications for factors modulating cell proliferation and differentiation, J.V. May
- rat thecal-interstitial cells in culture, D.A. Magoffin
- human theca interna cells in long-term culture, J.M. McAllister and E.R. Simpson
- dispersion, separation, and culture of the different cell populations of the rat, corpus luteum, S. Nelson and G. Gibori
- isolation and culture of fully differentiated bovine luteal cells, J.L. Pate
- isolation and culture of mouse uterine, epithelial and stroma cells, K.A. Ross et al.
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