Steroid hormone receptors : basic and clinical aspects
著者
書誌事項
Steroid hormone receptors : basic and clinical aspects
（Hormones in health and disease）
Birkhäuser, c1994
- : us
- : sw
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注記
Includes bibliographical references and indexes
内容説明・目次
- 巻冊次
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: us ISBN 9780817636944
内容説明
The past few years have witnessed the emergence of steroid hormones as the wonder molecules which generate as much discussion in the scientific literature as they do in a typical living room. This transition has been a result of the tremendous public and scientific interest in the normal functioning of the hor- mones as well their suggested involvement in several clinical conditions. In the recent past, notable scientific and technological advances have been made in the areas of contraception and regulation of fertility. Steroid receptors are the indis- pensable mediators of hormonal responses and are complex protein molecules which appear to exist in association with other, yet undefined, proteins and/or factors. Receptors for vitamin D, retinoic acid and the thyroid hormones share structural similarities with steroid receptors, and the roster of this superfamily is still expanding. While our knowledge of the diversity and magnitude of steroid effects has advanced, the precise mode of steroid hormone action has alluded investigators.
This volume brings together an international team of prominent investigators who discuss their most recent work on the basic and clinical aspects of steroid/nuclear receptors. The contributions represent updated versions of the invited presentations made at The Second Meadow Brook Conference on Steroid Receptors in Health and Disease. I am grateful to my colleagues on the Scientific Committee: Etienne Baulieu, Jack Gorski, Benita Katzenellenbogen, David Toft and James WittJiff, who provided the vision and guidance in formulating an out- standing program.
目次
I Introduction.- 1 Steroid/Nuclear Receptor Superfamily: Recent Advances and Relation to Health and Disease.- II Steroid Receptor Interactions with DNA and Nuclear Components.- 2 Structural and Functional Studies of Selective DNA Binding by Steroid/Nuclear Receptors.- 3 Estrogen Receptor Induced DNA Bending.- 4 The Nuclear Environment and Estrogen Action.- 5 Functional Interaction of the Estrogen Receptor with the Tissue-Specific, Homeodomain Transcription Factor, PIT-1.- 6 Insights into the Genomic Mechanism of Action of 1, 25-Dihydroxyvitamin D3.- 7 Molecular Mechanisms of Thyroid Hormone and Retinoic Acid Action.- III Receptor Structure and Associated Proteins.- 8 Heat Shock Proteins and the Cytoplasmic-Nuclear Trafficking of Steroid Receptors.- 9 In Vitro Assembly of the Avian Progesterone Receptor.- 10 Steroid Receptor Associated Proteins: Heat Shock Protein 90 and P59 Immunophilin.- 11 Estrogenic and Developmental Regulation of 90-Kilodalton Heat Shock Protein Gene Expression.- IV Receptor Modification and Hormone/Antihormone Interactions.- 12 Phosphorylation and Progesterone Receptor Function.- 13 Estrogen Receptor Activation by Ligand-Dependent and Ligand-Independent Pathways.- 14 Why Are Steroid Receptor Antagonists Sometimes Agonists?.- 15 Ligand Requirements for Estrogen Receptor Function and the Actions of Antiestrogens.- V Steroid Receptors and Clinical Correlations.- 16 Molecular Biological Aspects of the Human Androgen Receptor Relating to Disease.- 17 Estrogen Receptor Variants in Breast Cancer.- VI Emerging and Novel Systems.- 18 Human Bone Cells: Newly Discovered Target Cells for Sex Steroids.- 19 Characteristics of the Human Estrogen Receptor Protein Produced in Microbial Expression Systems.- 20 The Ah Locus: A Review.- Author Index.
- 巻冊次
-
: sw ISBN 9783764336943
内容説明
The past few years have witnessed the emergence of steroid hormones as the wonder molecules which generate as much discussion in the scientific literature as they do in a typical living room. This transition has been a result of the tremendous public and scientific interest in the normal functioning of the hormones as well their suggested involvement in several clinical conditions. In the recent past, notable scientific and technological advances have been made in the areas of contraception and regulation of fertility. Steroid receptors are the indispensable mediators of hormonal responses and are complex protein molecules which appear to exist in association with other, yet undefined, proteins and / or factors. Receptors for vitamin D, retinoic acid and the thyroid hormones share structural similarities with steroid receptors, and the roster of this superfamily is still expanding. While our knowledge of the diversity and magnitude of steroid effects has advanced, the precise mode of steroid hormone action has alluded investigators.
This volume brings together an international team of prominent investigators who discuss their most recent work on the basic and clinical aspects of steroid / nuclear receptors. The contributions represent updated versions of the invited presentations made at The Second Meadow Brook Conference on Steroid Receptors in Health and Disease. I am grateful to my colleagues on the Scientific Committee: Etienne Baulieu, Jack Gorski, Benita Katzenellenbogen, David Toft and James Wittliff, who provided the vision and guidance in formulating an outstanding program. The organizers gratefully acknowledge the financial support received from the conference sponsors, Oakland University, The Meadow Brook Hall, Serono Symposia, USA, William Beaumont Hospital, Schering-Plough Corporation, Eli Lilly & Company, The E.I. Du Pont De Nemours & Company, Affinity Bioreagents, Inc., and The Du Pont Merck Pharmaceutical Company. For the efficient execution of the conference program, I am indebted to my colleagues, Bill Underwood, Art Griggs, Amrita Bhakta and John Shiff.
The cooperation from the authors and the excellent secretarial assistance received from Rita Perris made the process of editing this volume an enjoyable and memorable experience. I am also pleased to extend my warmest wishes and cooperation to the publisher, Birkhauser Boston, who has decided to introduce a new series, Hormones in Health and Disease, with the present volume as the inaugural issue.
目次
Preface List of Contributors Part I Introduction 1 Steroid / Nuclear Receptor Superfamily: Recent Advances and Relation to Health and Disease V K Moudgil Part II Steroid Receptor Interactions with DNA and Nuclear Components 2 Structural and Functional Studies of Selective DNA Binding by Steroid / Nuclear Receptors Leonard P Freedman, Ben F Luisi, Iris Alroy, and Terri L. Towers 3 Estrogen Receptor Induced DNA Bending David J. Shapiro, Geoffrey L. Greene, and Ann M. Nardulli 4 The Nuclear Environment and Estrogen Action Jerry R. Malayer and Jack Gorski 5 Functional Interaction of the Estrogen Receptor with the Tissue-Specific, Homeodomain Transcription Factor, PIT- 1 Richard A. Maurer, Richard N. Day, Yasuhiko Okimura, and Barbara E. Nowakowski 6 Insights into the Genomic Mechanism of Action of 1,25-Dihydroxyvitamin D3 J. Wesley Pike 7 Molecular Mechanisms of Thyroid Hormone and Retinoic Acid Action Magnus Pfahl Part III Receptor Structure and Associated Proteins 8 Heat Shock Proteins and the Cytoplasmic-Nuclear Trafficking of Steroid Receptors William B. Pratt and Lawrence C. Scherrer 9 In Vitro Assembly of the Avian Progesterone Receptor David F Smith, William P Sullivan, Jill Johnson, and David O. Toft 10 Steroid Receptor Associated Proteins: Heat Shock Protein 90 and P59 Immunophilin Mane-Claire Lebeau, Nadine Binart, Frangoise Cadepond, Maria-Grazia Catel, Beatrice Chambraud, Nelly Massol, Christine Radanyi, Gerard Redeuilh, Jack-Michel Renoir, Michele Sabbah, Ghislaine Schweizer- Groyer, and Etienne-Emile Baulieu 11 Estrogenic and Developmental Regulation of 90-Kilodalton Heat Shock Protein Gene Expression G. Shyamala Part IV Receptor Modification and Hormone / Antihormone Interactions 12 Phosphorylation and Progesterone Receptor Function Nancy L. Weigel, Angelo Poletti, Candace A. Beck, Dean P Edwards, Timothy H. Carter, and Larry A. Denner 13 Estrogen Receptor Activation by Ligand-Dependent and Ligand-Independent Pathways Carolyn L. Smith, Orla M. Conneely, and Bert W. O'Malley 14 Why Are Steroid Receptor Antagonists Sometimes Agonists? Kathryn B. Horwitz and Kimberly K. Leslie 15 Ligand Requirements for Estrogen Receptor Function and the Actions of Antiestrogens Joseph C. Reese and Benita S. Katzenellenbogen Part V Steroid Receptors and Clinical Correlations 16 Molecular Biological Aspects of the Human Androgen Receptor Relating to Disease Zhong-xun Zhou, Madhabananda Sar, Frank S. French, and Elizabeth M. Wilson 17 Estrogen Receptor Variants in Breast Cancer Carlos A. Encamacion and Suzanne A. W Fuqua. Part VI Emerging and Novel Systems 18 Human Bone Cells: Newly Discovered Target Cells For Sex Steroids Thomas C. Spelsberg, Merry Jo Oursler, James P Landers, Malayannam Subranianiam, Steven A. Harris, and B. Lawrence Riggs 19 Characteristics of the Human Estrogen Receptor Protein Produced in Microbial Expression Systems James L. Wittfiff, Jing Dong, Christine Schaupp, Peter Folk, and Tauseef Butt
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