Advances in neutron capture therapy
著者
書誌事項
Advances in neutron capture therapy
Plenum Press, c1993
大学図書館所蔵 全4件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
"Proceedings of the Fifth International Symposium on Neutron Capture Therapy, held September 14-17, 1992, in Columbus, Ohio"--T.p. verso
"International Society for Neutron Capture Therapy; UICC; The Arthur G. James Cancer Hospital and Research Institute"-T.p. verso
Includes bibliographical references and index
内容説明・目次
内容説明
Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
目次
Nuclear Physics and Engineering: Reactor Beams-Thermal. Reactor Beams-Epithermal. Acceleratory and Isotropic Neutron Sources. Dosimetry: Treatment Planning and Beam Evaluation. Microdosimetry. Gadolinium Neutron Capture Therapy. Compound Development: Small Molecular Weight Compunds: Amino Acids. Nucleosides, Nucleotides, Carbohydrates, and Polyols. Polyphyrins, Aziridines, and Nitromidazole. Miscellaneous Compounds. Compound Development: Macromolecules, Analytical: Quantitative Measurements. Radiographic and Miscellaneous Analytical Studies. Biological Studies: Small Animal Studies: Pharmacokinetics. Small Animal Studies: Therapy. Large Animal Studies: Normal Tissue Tolerance. Large Animal Studies: Pharmacokinetics. Large Animal Studies: Treatment Planning. In vitro Studies. RBE of the 10 B(n,alpha)7 Reaction. Clinical Studies: Treatment of Brain Tumors and Arteriovenous Malformations. Treatment of Melanoma. Pharmacokinetic and Biodistribution Studies. Planning for Clinical Trials. In Summary. 157 articles. Index.
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