Nucleosides and nucleotides as antitumor and antiviral agents
著者
書誌事項
Nucleosides and nucleotides as antitumor and antiviral agents
Plenum Press, c1993
大学図書館所蔵 全3件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
"Proceedings of an American Chemical Society Carbohydrate Division Symposium on Nucleosides as Antitumor and Antiviral Agents: Tohru Ueda Memorial Symposium, held April 7, 1992, in San Francisco, California"--T.p. verso
Includes bibliographical references and index
内容説明・目次
内容説明
Due to the worldwide epidemic of acquired immunodeficiency syndrome (AIDS), the past ten years have witnessed a flurry of activity in the chemotherapy of viral diseases. Unprecedented scientific efforts have been made by scientists and clinicians to combat infections of human immunodeficiency virus (HIY), the causative agent. Looking back over the past ten years, we have made remarkable progress toward the treatment of the viral disease: isolation of HIV only two years after the identification of the disease, plus major strides in the areas of the molecular biology and virology of the retrovirus, etc. More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease. The last six to seven years have particularly been an exciting and productive period for nucleoside chemists. Since the activity of AZI' was established in 1985, nucleoside chemists have had golden opportunities to discover additional anti-HIV nucleosipes, which are hoped to be less toxic and more effective than AZT, and the opportunity continues. As we all are aware, AZT possesses extremely potent anti-HIY activity, and no other nucleoside or non nucleoside has surpassed the potency of AZT in vitro.
目次
Design of New Types of Antitumor Nucleosides (A. Matsuda et al.). Lithiation Chemistry of Uridine Derivatives (H. Tanaka et al.). A Synthesis of 2'Fluoro and 3'FluoroSubstituted Purine Nucleosides via a Direct Approach (K.W. Pankiewicz, K.A. Wantanabe). Allenols Derived from Nucleic Acid Bases-A New Class of AntiHIV Agents (J. Zemlicka). StructureActivity Relationships among HIV Inhibatory, 4'Substituted Nucleosides (E.J. Prisbe et al.). Approaches to Novel Isomeric Nucleosides as Antiviral Agents (V. Nair). Carbocyclic 7Deazaguanosine Nucleosides as Antiviral Agents (S.W. Schneller et al.). Synthesis and Anticancer and Antiviral Activity of Certain Pyramidine Nucleoside Analogues (T.S. Lin, M.C. Liu). Stereocontrolled Routes for the Synthesis of AntiHIV and AntiHBV Nucleosides (J.W. Beach et al.). 5Substituted Arabinofuranosyluracil Nucleosides as Antiherpes Agents (H. Machida, S. Sakata). 6 additional articles. Index.
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