Growth hormone and somatomedins during lifespan
Author(s)
Bibliographic Information
Growth hormone and somatomedins during lifespan
Springer-Verlag, c1993
- : gw
- : us
Available at 2 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Papers based on the proceedings of the Sixth Congress held in Milan, 1992
Includes bibliographical references and index
Description and Table of Contents
Description
The various congresses on growth hormone (GH) which have been held in Milan since 1967, the Milan Congresses, have witnessed over 25 years the tremendous expansion of a research field that was based initially upon the scarce knowledge of the biological properties of a protein. GH, whose chemical structure had just been identified and a radioimmunoassay developed for its measurement in blood, became in the following years a major area of biological research. The boundaries have since become blurred, as the research area has extended to the physiology and pathology of growth, puberty and reproduction, and the control of metabolism during the whole lifespan. Since the last GH Congress held in 1987, GH studies using the molecular biological approach have resulted in the puri- fication, cloning and expression of the human GH (hGH) recep- tor and binding protein, in new and exciting information on the insulin-like growth factors (IGF) and their paracrine and autocrine roles, and in the awareness that a panoply of binding proteins are present in the extracellular fluids and can, possibly, modulate IGF-receptor interactions and, thus, IGF actions.
Finally, the availability of large amounts of biosynthetic hGH, besides allow- ing more extensive clinical use in states of GH deficiency and extrasomatotrophic pathologies, has permitted disclosure of im- portant metabolic effects of hGH during adulthood and, perhaps, aging and in many protein catabolic states.
Table of Contents
Growth Hormone.- Growth Hormone: Neural Mechanisms of Control at Neonatal and Aged Periods.- Studies on Peptide 23: A GHRH-Regulated Protein of the Pituitary and Gastrointestinal Tract.- Biochemistry and Cellular Distribution of the Growth Hormone Receptor.- Cellular Transfection of GH Receptor cDNA to Study GH Action.- Somatomedins.- Molecular Biology of the Somatomedins.- Tissue Expression of Insulin-like Growth Factor I.- Insulin-like Growth Factor Receptors and Signaling Mechanisms.- Regulation of Insulin-like Growth Factor-I by Nutrition.- Insulin-like Growth Factor Binding Proteins: Biochemical Characterization.- Role of Insulin-like Growth Factor Binding Proteins in Modulating Insulin-like Growth Factor Action.- Autocrine and Paracrine Effects of Insulin-like Growth Factors and Their Binding Proteins.- Fetal and Neonatal Growth.- Use of Transgenic and Genetic Models to Study the Neuroendocrine Regulation of Growth Hormone Secretion.- Biosynthesis and Biological Role of Insulin-like Growth Factors in the Nervous System.- Mechanisms of Intrauterine Growth Retardation: Role of Fetal and Maternal Hormones.- Growth Hormone Treatment of Children with Intrauterine Growth Retardation.- Plenary Lecture.- Growth Hormone, Insulin-like Growth Factor I and Immune Function.- Pubertal Development.- Regulation of Female Sexual Development by Neurotrophic Factors.- Effects of Nutrition and Growth Related Hormones on Pubertal Development.- Effects of Physical Exercise on Growth and Pubertal Development.- Effects of Gonadal Steroid Hormones on Growth and Growth Hormone Secretion at Puberty in Humans.- Plenary Lecture.- Potential Therapeutic Uses of Insulin-like Growth Factor I.- Adulthood and Senescence.- The Somatopause.- Neural Control of Growth Hormone Secretion in Aged Humans.- Growth Hormone Treatment in Adults with Growth Hormone Deficiency.- Effects of Growth Hormone on Bone and Calcium Metabolism in Older People.- Skeletal Growth: A New Parameter in the Evaluation of Experimental Arthritis.- Anabolic Effects of Growth Hormone Administration in Adults.- Long-Term Growth Hormone Therapy in Adulthood: Potential Risk and Benefits.
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