The calculation of genetic risks : worked examples in DNA diagnostics
著者
書誌事項
The calculation of genetic risks : worked examples in DNA diagnostics
Johns Hopkins University Press, c1994
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注記
Includes bibliographical references (p. [187]-189) and index
内容説明・目次
内容説明
The author declares that the basic aim of this book is to impart the fundamentals of the way in which he begins with laboratory results and ends up with numbers representing genetic risks. Intended as a practical guide for both clinical and research geneticists, it explains how to calculate an individual's genetic risk based on information from genetic testing and family pedigrees. The author starts with the general theory of estimating genetic risks and progresses through familial and isolated cases, both simple and complex. Worked examples are provided throughout the text. The disorders are selected to be widely applicable or adaptable as needed.
目次
- The estimation of genetic risks
- Bayesian risk calculations for X-linked recessive disorders
- incorporation of females with biochemical test results into Bayesian calculations
- pedigree risks in autosomal conditions
- introduction to DNA polymorphisms
- statistical approaches to gene mapping
- use of DNA polymorphisms in predicting genetic risks
- introduction to the integration of RFLP data with non-DNA parameters.
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