Resistance to antitumor agents : laboratory and clinical studies : proceedings of a course held at the International School of Pharmacology, Ettore Majorana Centre for Scientific Culture, Italy, 13-18 April 1988
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Bibliographic Information
Resistance to antitumor agents : laboratory and clinical studies : proceedings of a course held at the International School of Pharmacology, Ettore Majorana Centre for Scientific Culture, Italy, 13-18 April 1988
（Ettore Majorana international life sciences series, v. 7）
Harwood Academic Publishers, c1989
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Includes bibliographical references
Includes index
Description and Table of Contents
Description
This work is based on lectures given at the Ettore Majorana Centre's 25th Course on "Resistance to Anti-tumour Agents in the Laboratory and Clinic: Problems and Implications from 13 to 18 April 1988". In the last few decades extensive research worldwide has led to the discovery of a number of compounds with properties that inhibit the proliferation of neoplastic cells. These compounds make up a large array of therapeutic agents now available to the physician treating cancer patients. Experimental evidence and controlled clinical trials, however, have shown that the failure to reach expected goals during treatment is due principally to the emergence of drug resistance cancer cell clones. The neoplastic cell has multifarious pathways options, enabling its survival and multiplication in the presence of inhibitors. The therapist's task is to design regimens using single or combined treatments in order to prevent or circumvent the obstacle of drug resistance. This book is intended to bring clinical oncologists up to date with the problem and to stimulate further work in the field.
Table of Contents
- The role of moral associations in cancer research, G.Venosta
- implications of resistance as related to known drugs, E.Mihich et al
- relationship between "in vitro" drug efficacy and effectiveness, H.Tapiero et al
- molecular approaches to antiviral chemotherapy of acquired immune deficiency syndrome, P.Chandra et al
- investigations of anti-tumour drug resistance using human tumour cell lines "in vitro", B.T.Hill et al
- relationship between pharmacokinetic and resistance and clinical methods and techniques related to circumvention of tumour resistance, B.Berkarda
- glutathione S-transferases in drug resistance, K.D.Tew and M.L.Clapper
- cell kinetic modulations to overcome drug resistance, A.Alama et al
- studies on anthracyclines resistance - an experimental model, D.Ballinari et al
- determinants of response to adriamycin in sensitive and resistant P-388 cells and their modulation, I.Bankusli et al
- biochemical and biological changes accompanying resistance to doxorubicin, H.Tapiero et al
- management of breast cancer patients resistant to chemotherapy, E.Galligioni et al
- resistance to hormone therapy in prostatic cancer, C.Pavone et al
- management of lymphomas resistant to conventional chemotherapeutic regimens - biological approach, high dose chemotherapy and bone marrow transplantation, F.Grignani et al
- chemoresistance in colonic and ovarian cancer, M.Fiorentino and S.Toso
- estracyt - a drug with a novel mechanism of cytotoxicity, K.D.Tew and M.E.Stearns
- what is the meaning of the word "radioresistance"? L.Magno
- radiobiology of cellular resistance, M.Bignardi and F.Bertoni
- microwave and radiofrequency hyperthermia as a tool to overcome radioresistance, G.L.Sannazzari et al
- lonidamine - a new pharmacological way for overcoming radioresistance, B.Silvestrini
- antigenic modification of cancer cells mediated by drug-cell interaction, S.D'Atri et al
- immunological effector mechanisms as tools to deal with drug resistant tumour variants, P.Allavena et al
- biological properties and clinical usage of interferons, A.M.Liberati et al.
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