Treatment of age-related cognitive dysfunction : pharmacological and clinical evaluation
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Bibliographic Information
Treatment of age-related cognitive dysfunction : pharmacological and clinical evaluation
（International Academy for Biomedical and Drug Research, vol. 2）
Karger, c1992
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Includes bibliographical references and index
Description and Table of Contents
Description
Cognitive disorders of later life range in severity from the learning and memory deficits seen in normal ageing to the global failure of cognitive function that marks the final stages of Alzheimer's disease. The contributions in this volume focus on basic and clinical aspects of age-related cognitive dysfunction. Neurochemical, electrophysiological as well as molecular and genetic studies are reported, providing a rational basis for the definition and treatment of these disorders. Further papers discuss the development of cognitive enhancers and the associated clinical assessment methodology. In addition, a panel discussion summary is included which represents a consensus document on key regulatory issues in the development of these pharmacological agents.
Table of Contents
- Failure of integrative mechanisms in the ageing brain, K. Fuxe et al
- cholinergic mechanism and trophic factors, M. Knipper and H.I. Yamamura
- age-related quantitative and qualitative receptor changes and pharmacological reactivity, W.E. Muller
- amino acid receptors and long-term potentiation - targets for the development of cognitive enhancers, G.L. Collingridge et al
- preclinical evaluation of potential cognition enhancers, R.D. Porsolt et al
- morphological brain changes induced by alcohol and ageing - effects of piracetam during withdrawal following long-term alcohol consumption, F. Brandao et al
- age-associated memory impairment, K.C. Raffaele et al
- Alzheimer's disease is caused by mismetabolism of the beta-amyloid precursor protein, J. Hardy
- definition and classification of age-related cognitive dysfunction, L. Amaducci et al
- assessment of clinical efficacy of cognitive enhancers, T.H. Crook
- developing pharmacological treatment for age associated cognitive impairments - a regulatory perspective, P. Leber
- impact of European regulations in drug development, F. Sauer
- reappraisal of current therapy in the treatment of age-related cognitive disorders, C.G. Gottfries
- interaction between cognitive and pharmacological treatment in age-related cognitive impairment, W. Deberdt
- the next decade in drug treatment of cognitive disorders, C.E. Giurgea
- panel discussion - regulatory issues in the development of drugs for the treatment of cognitive dysfunctions, L. Amaducci et al.
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