Coronary thrombolysis in perspective : principles underlying conjunctive and adjunctive therapy

著者

書誌事項

Coronary thrombolysis in perspective : principles underlying conjunctive and adjunctive therapy

edited by Burton E. Sobel, Désiré Collen

（Fundamental and clinical cardiology, v. 16）

M.Dekker, c1993

大学図書館所蔵 件 / 全2件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This work clinically reviews advances in coronary thrombolysis and offers practical information for the optimal implementation of conjunctive and adjunctive measures needed when coronary thrombolysis is performed. It presents results of the GUSTO trial and discusses anticoagulants under development, including direct acting thrombins, inhibitors of coagulation factor X and tissue factor, and antiplatelet drugs. Illustrating methods and techniques that induce patency of thrombotically occluded coronary arteries, this work: introduces the concept of conjunctive therapy and differentiates it from adjunctive therapy; assesses the advantages and disadvantages of specific fibrinolytic agents for use in particular clinical circumstances; clarifies mechanisms underlying atherogenesis, coronary thrombosis and acute coronary syndromes; identifies the clinical considerations that must be addressed if coronary thrombosis is to be optimally effective; shows how fibrinolytic agents act as procoagulants; describes the relationship between the fibrinolytic system and the activation of platelets; and provides practical protocols for the use of clot-selective and nonclot-slective drugs to treat coronary thrombosis.

目次

  • Coronary thrombolysis - background and factors underlying its emergence, Burton E. Sobel
  • thrombolytic agents, Desire Collen and Mark Verstaete
  • the nature of atherosclerotic lesions giving rise to acute coronary thrombolysis, Eric Falk and Il Kyung Jang
  • the objectives of coronary thrombolysis, David de Bono
  • the impact of time to treatment on the efficacy of coronary thrombolysis, Burton E. Sobel
  • procoagulent effects of fibrinolytic agents, Paul R. Eisenberg
  • the role of platelets in thrombolysis, thrombosis and thrombolytic therapy, Edward F. Plow
  • relationships between suppression of coagulation and prevention of reocclusion, Dana R. Abendschein
  • strengths and limitations of specific antithrombotic regimens and agents, Jack Hirsh
  • discrepancies between end-point results in clinical trials of thrombolytic therapy - the salvage paradigm revisited, Frans Van de Werf
  • coronary artery patency, Alan J. Tiefenbrunn
  • mortality as an end point in studies of coronary thrombosis, Burton E. Sobel
  • clinical factors militating against sustained patency and their consequences, Stanley D. Belich
  • efficacy of currently available conjunctive regimens, Uwe Zeymer and Karl-Ludwig Neuhaus
  • myocardial reperfusion injury - concepts, mechanisms and therapeutic strategies, Jean-Louis J. Vanoverschelde and Steven R. Bergmann
  • Epilogue - controversy and clarification - preliminary results of the GUSTO trial, Burton E. Sobel and Desire Collen.

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