Coronary thrombolysis in perspective : principles underlying conjunctive and adjunctive therapy
Author(s)
Bibliographic Information
Coronary thrombolysis in perspective : principles underlying conjunctive and adjunctive therapy
(Fundamental and clinical cardiology, v. 16)
M.Dekker, c1993
Available at 2 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
This work clinically reviews advances in coronary thrombolysis and offers practical information for the optimal implementation of conjunctive and adjunctive measures needed when coronary thrombolysis is performed. It presents results of the GUSTO trial and discusses anticoagulants under development, including direct acting thrombins, inhibitors of coagulation factor X and tissue factor, and antiplatelet drugs.
Illustrating methods and techniques that induce patency of thrombotically occluded coronary arteries, this work: introduces the concept of conjunctive therapy and differentiates it from adjunctive therapy; assesses the advantages and disadvantages of specific fibrinolytic agents for use in particular clinical circumstances; clarifies mechanisms underlying atherogenesis, coronary thrombosis and acute coronary syndromes; identifies the clinical considerations that must be addressed if coronary thrombosis is to be optimally effective; shows how fibrinolytic agents act as procoagulants; describes the relationship between the fibrinolytic system and the activation of platelets; and provides practical protocols for the use of clot-selective and nonclot-slective drugs to treat coronary thrombosis.
Table of Contents
- Coronary thrombolysis - background and factors underlying its emergence, Burton E. Sobel
- thrombolytic agents, Desire Collen and Mark Verstaete
- the nature of atherosclerotic lesions giving rise to acute coronary thrombolysis, Eric Falk and Il Kyung Jang
- the objectives of coronary thrombolysis, David de Bono
- the impact of time to treatment on the efficacy of coronary thrombolysis, Burton E. Sobel
- procoagulent effects of fibrinolytic agents, Paul R. Eisenberg
- the role of platelets in thrombolysis, thrombosis and thrombolytic therapy, Edward F. Plow
- relationships between suppression of coagulation and prevention of reocclusion, Dana R. Abendschein
- strengths and limitations of specific antithrombotic regimens and agents, Jack Hirsh
- discrepancies between end-point results in clinical trials of thrombolytic therapy - the salvage paradigm revisited, Frans Van de Werf
- coronary artery patency, Alan J. Tiefenbrunn
- mortality as an end point in studies of coronary thrombosis, Burton E. Sobel
- clinical factors militating against sustained patency and their consequences, Stanley D. Belich
- efficacy of currently available conjunctive regimens, Uwe Zeymer and Karl-Ludwig Neuhaus
- myocardial reperfusion injury - concepts, mechanisms and therapeutic strategies, Jean-Louis J. Vanoverschelde and Steven R. Bergmann
- Epilogue - controversy and clarification - preliminary results of the GUSTO trial, Burton E. Sobel and Desire Collen.
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