Monoamine oxidase : basic and clinical aspects
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書誌事項
Monoamine oxidase : basic and clinical aspects
VSP, 1993
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注記
Includes bibliographical references
内容説明・目次
内容説明
Monoamine oxidase (MAO), a mitochondrial enzyme which metabolizes monoamines in both the central nervous system and peripheral tissues, plays an important role in the regulation of neuronal activities by controlling the concentrations of monoamines. During the past three decades the enzymological properties of MAO have been studied extensively. The most exciting and important advances in these studies have been the determination of the nucleotide sequence coding two forms of human MAO (MAO-A and MAO-B), and the involvement of MAO in potent dopaminergic neurotoxicity of MPTP, which had led to the acceleration of aetiological studies of Parkinson's disease. Other aspects of MAO studies have been the application of selective and safe MAO inhibitors in the treatment of depression and Parkinson's disease as well as the correlation between MAO and several psychiatric and neurodegenerative disorders.
目次
Preface
Newer approaches to the study of monoamine oxidase inhibition
K.F. Tipton, D. Balsa and M. Unzeta
cDNA cloning of human liver MAO-A and MAO-B
J.C. Shih
New aspects of the substrate specificities, kinetic mechanisms and inhibition of monoamine oxidase
T.P. Singer and R.R. Ramsay
Isoquinolines and quinolines as inhibitors and substrates of monoamine oxidase
M. Naoi, H. Parvez and T. Nagatsu
Tribulin and isatin: an update
V. Glover and M. Sandler
Endogenous MAO inhibitors in brain
T. Egashira
Hepatotoxicity of monoamine oxidase inhibitors in isolated and primary cultured hepatocytes of rat
M. Tsuji, K. Kodama, M. Okazaki, H. Yasuhara and K. Oguchi
MAO in hypertension
M. Minami, H. Matsuda, N. Hamaue, Y. Monma, N. Yamazaki, H. Togashi, M. Yoshioka, H. Saito and H. Parvez
A role for monoamine oxidase in the development of Parkinson's disease?
H. Kinemuchi, Y. Arai and C.J. Fowler
Localization and activity of multiple forms of MAO in human eye
E. Uchida, K. Oguchi, Y. Kiuchi and H. Yasuhara
Human brain MAO
M. Gerlach and P. Riederer
Reversible monoamine oxidase inhibitors: from laboratory to clinic
A.M. Cesura, J.G. Richards, G.B. Picotti, R. Kettler, R. Imhof and M. Da Prada
Clinical pharmacology of MAO inhibitors
P.R. Bieck, K.-H. Antonin and R. Schulz
Some clinical implication of MAO-B inhibition
J. Knoll
Monoamine oxidase in neuro-psychiatric disorders
L. Oreland
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