Hemopoietic growth factors, oncogenes, and cytokines in clinical hematology : current aspects and future directions
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Bibliographic Information
Hemopoietic growth factors, oncogenes, and cytokines in clinical hematology : current aspects and future directions
Karger, c1994
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Includes bibliographical references and index
Description and Table of Contents
Description
Several significant discoveries have been reported over the past few years concerning the role of extracellular factors in the proliferation and differentiation of hemopoietic cells. This volume describes the latest advances in our understanding of the biological events underlying the development of hemopoietic neoplasms. The first part of the book discusses the mechanisms regulating the cell proliferation. In this context the cooperation between growth factors/cytokines and oncogenes in the development of hematological neoplasia is surveyed. The second part focuses on the mechanisms leading to malignant transformation. The use of specific hemopoietic growth factors and cytokines in the management of lymphohemopoietic is summarized in the final part. The book will give hematologists, oncologists and immunologists a timely update on progress in this important field of investigation and on new directions in the therapy of hemopoietic malignancies.
Table of Contents
- Part 1 Mechanisms regulating cell proliferation: relationship between growth factors oncogenes and cytokines in the mechanism of aberrant hematopoiesis, G.A. Palumbo et al
- the role of hematopoietic stromal cells in the regulation of hematopoiesis, M.C. Heinrich and G.C. Bagby
- proliferation, differentiation and programmed cell death - an outline of their genetic control and disorders in normal and leukemic myelopoiesis, U. Torelli et al
- cytokines that inhibit tyrosine kinase activity - receptor structure and signal transduction, J.D. Watson et al
- receptor signal transduction and cytokine gene expression in T lymphocytes, R. Testi et al. Part 2 Mechanisms leading to malignant cell transformation: altered surface immunoregulatory proteins in myeloid leukemias, D.F. Claxton et al
- loss of growth regulatory molecules in leukemia, L. Nagarajan
- cell kinetic molecular and clinical analysis of growth factor sensitization of myeloid leukemia, M. Andreeff et al
- regulation of drug sensitivity in cultures of the blast stem cells of acute myeloblastic leukemia, E.A. McCulloch
- molecular pathogenesis of acute promyelocytic leukemia, F. Grignani et al. Part 3 Hemopoietic growth factors/cytokines in the management of lymphohemopoietic malignancies: advances in the biology and treatment of chronic myelogenous leukemia, I. Khouri and A.B. Deisseroth
- the use of growth factor receptor inhibitors in human neoplasms, Z. Estrov et al.
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