Life during a golden age of peptide chemistry : the concept and development of solid-phase peptide synthesis

書誌事項

Life during a golden age of peptide chemistry : the concept and development of solid-phase peptide synthesis

Bruce Merrifield

(Profiles, pathways, and dreams : autobiographies of eminent chemists)

American Chemical Society, 1993

  • : pbk

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注記

Bibliography: p. 259-273

Includes index

内容説明・目次

内容説明

Bruce Merrifield, eminent American scientist, 1984 Nobel Prize winner and professor at The Rockefeller University, is noted for his single-handed development of solid phase peptide synthesis. The progress of biochemistry and related fields is closely correlated with the availability of pure peptides, and in this volume, Merrifield describes nearly 40 years of progress. The warmth and kindness of this sincere gentleman is described by his personal experiences. Many photographs depict both the professional as well as the personal side of Bruce Merrifield.

目次

  • Why chemistry?
  • background
  • early exposures to science
  • the university period
  • nucleic acid studies
  • two trips east
  • the Rockefeller Institute
  • peptides
  • solid-phase peptide synthesis
  • the Rockefeller University
  • variations in solid-phase synthesis design
  • automation
  • the second stage of solid-phase peptide synthesis
  • properties of the resin support
  • recent developments in the chemistry
  • further syntheses of biologically-active peptides
  • antagonists of glucagon
  • my families
  • unexpected rewards
  • awards
  • the future.

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