Drug toxicokinetics
著者
書誌事項
Drug toxicokinetics
（Drug and chemical toxicology, v. 9）
Marcel Dekker, c1993
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This reference/text examines the importance of toxicokinetics on drug disposition and outlines its practical applications in drug development - helping readers incorporate the most up-to-date findings into their own work.;Consolidating research from international authorities in the fields of toxicology, pharmacokinetics, metabolism and biochemistry to illustrate the interdisciplinary nature of toxicokinetic situations, Drug Toxicokinetics: covers regulatory guidelines for conducting toxicokinetic studies to obtain maximum information for safety assessment and clinical use of drug candidates; illustrates the principles of linear and nonlinear pharmacokinetics and compares them to toxicokinetics; displays relationships between the time-span of drug concentrations in the body and the appearance of toxic effects; and spotlights problems and solutions regarding metabolism impact in toxicology as well as the bioactivation of drugs.;Containing over 950 literature citations, figures and tables, Drug Toxicokinetics is intended as a reference for pharmacists; organic and medicinal chemists; industrial, academic and government pharmacologists and toxicologists; pharmacokineticists; safety-evaluation scientists; pathologists and biochemists. It should also be a useful guide for personnel in public health, risk assessment, chemical industry, drug metabolism and drug regulatory affairs as well as for clinical and preclinical drug development scientists. The book should also serve as a useful text for upper-level undergraduate and graduate students in these disciplines.
目次
- Analytical method considerations for toxicokinetic studies, D. Scott Wright
- pharmacokinetic principles - linear and nonlinear, Peter G. Welling
- biotransformation of xenobiotics to chemically reactive metabolites, Neal Castagnoli, Jr., and Kay P. Castagnoli
- role of toxicokinetics in dose selection for carcinogenicity studies, Mitchell N. Cayen and Hugh E. Black
- toxicokinetic study design and integrated programmes, Eva Halperin-Walega, et al
- role of toxicokinetics in toxicity testing, L.F. Chasseaud
- relation between toxicity and kinetics and models of renal disease, Norberto Perico and Silvio Garattini
- route of administration and toxicity, Lloyd Dethloff
- genetic variations in humans and toxicokinetics, Bert N. La Du, Jr.
- comparative histokinetic and xenodynamic considerations in toxicity, Michael J. Iatropoulos
- toxicokinetics of anticancer compounds, Lloyd R. Whitfield and David G. Pegg
- toxicokinetics of chemical carcinogens, Anthony J. Streeter
- application of toxicokinetic principles in the developoment of antiatherosclerotic compounds, Robert L. Susick and Thomas Woolf
- toxicokinetics of drugs acting on the central nervous system, D. Scott Wright, et al
- toxicokinetics of antibacterial agents - pre-clinical perspective, Robert D. Smyth and Robert J. Smyth
- perspective and future directions of toxicokinetics in drug development, Felix A. de la Iglesia.
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