Neuromuscular transmission : basic and applied aspects
著者
書誌事項
Neuromuscular transmission : basic and applied aspects
（Pergammon studies in neuroscience, no. 3）
Pergamon Press, 1992
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注記
"First edition 1990 by Manchester University Press"--T.p. verso
Includes bibliographical references and index
内容説明・目次
内容説明
The unique isolated situation and ready accessibility of the neuromuscular junction has made the whole process of neuromuscular transmission a prototype for synaptic interactions in general. Over the last two decades, the study of neuromuscular transmission has evolved to the extent that many of the events can be identified at the molecular level and related to specific membrane proteins. This book, a collection of chapters written by acknowledged field leaders, provides an up-to-date, comprehensive review of this multidisciplinary subject. It is roughly divided into three sections. The introductory chapters draw a molecular picture of the structure and development of the neuromuscular junction, and summarise basic electrophysiology and general techniques. These are followed by chapters on the biochemistry of ACh and the biophysics of ACh/AChR interactions, and the molecular biology of the AChR and of the various voltage-dependent ion channels, with particular reference to the use of neurotoxins and antibodies in characterisation and structural analysis.
目次
- List of contributors. Preface. Structure and development of the neuromuscular junction, C. Slater & A. Vincen
- . Electrophysiology of neuromuscular transmission, D. Wray. Techniques used in the study of neuromuscular transmission, D. Wray et al. Synthesis, storage and release of acetylcholine, P. Molenaar. Properties of ion channels involved in neuromuscular transmission, R. Norman. Functional components at nerve terminals revealed by neurotoxins, O. Dolly. Agonists, antagonists and synaptic transmission at the neuromuscular junction, D. Colquhoun. Acetylcholine receptors at the neuromuscular junction, D. Beeson & E. Barnar
- . Monoclonal antibodies in the study of acetylcholine receptors, J. Lindstrom. Congenital myasthenic syndromes, A. G. Engel. Myasthenia gravis - an autoimmune disorder of neuromuscular transmission, A. Vincent. The Lambert-Eaton myasthenic syndrome, D. Wray. Experimental autoimmune myasthenia gravis, M. De Baets. Index.
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