Biomarkers of human exposure to pesticides : developed from a symposium sponsored by the Division of Agrochemicals at the 204th National Meeting of the American Chemical Society, Washington, DC, August 23-28, 1992
著者
書誌事項
Biomarkers of human exposure to pesticides : developed from a symposium sponsored by the Division of Agrochemicals at the 204th National Meeting of the American Chemical Society, Washington, DC, August 23-28, 1992
（ACS symposium series, 542）
American Chemical Society, 1994
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注記
Includes bibliographical references and indexes
内容説明・目次
内容説明
This work is developed from a symposium sponsored by the Division of Agrochemicals at the 204th National Meeting of the American Chemical Society, Washington, DC, USA, August 24-28, 1992. This study explores the role of biomarker data in evaluating the impact of human environmental and occupations exposure to pesticides, and discusses two basic types of biomarkers - residue analysis of parent compounds or metabolites and endpoints representing interactions between xenobiotic and endogenous components like enzyme inhibition, mutation, protein adducts, receptor complexes and antibody-antigen complexes. The book also: characterizes the molecular basis for various biomarker methods, and examines structure activity relationships; surveys biomarker measurement methods currently used in the research community; and examines methods for biomarker data analysis and applications of these methods to risk assessment.
目次
- Introduction: Biomonitoring for pesticide exposure, C.H. Nauman et al. Part 1 Modeling cytochrome P-450 mediated acute nitrile toxicity using theoretical linear solvation energy relationships, George R. Famini et al
- changes in biochemical and molecular biological parameters induced by exposure to dioxin-type chemicals, Alan Blankenship and Fumio Matsumura
- regulation of muscarine receptors as biomarkers of exposure to insecticides, Amira T. Eldefrawi et al
- correlations of molecular connectivity indices with toxicities of organic nitriles, Gordon C. Cash
- computer-aided molecular modeling for development of biomarkers for human exposure to pesticides, Mahmoud A. Saleh et al. Part 2 Biomarker measurement methods: a biosensor for monitoring blood cholinesterases as a biomarker of exposure to organophosphorus anticholinesterase pesticides, Mohyee E. Eldefrawi et al
- hair as a target tissue for developing a biological marker for precursors to 2,5-hexanedione, Deadre J. Johnson et al
- haemoglobin adducts of pesticides, Frank C. Schnell
- immunoassay for p-nitrophenol in urine, Kim R. Rogers and J.M. Van Emon
- isolation of pesticide-binding protein from rat blood, G.L. Larsen et al
- body burden and non-occupational exposure assessment, John A. Santolucito
- chronic organophosphorus exposure - biomarkers in the detection of immune dysfunction and the development of lymphomas, David S. Newcombe et al. Part 3 Data analysis and application to risk assessment: validation of a pharmacokinetic model to predict exposure of ground boom mixer-loader-applicators to chlorophenoxyacetic acid herbicides - comparison to conventional approaches, D.G. Baugher
- dermal absorption and disposition of formulations of malathion in Sprague-Dawley rats and humans, Curtis C. Dary et al
- physiologically-based pharmacokinetic models - examples of their use in exposure and risk assessment, Jerry N. Blancato and Mahmoud A. Saleh
- prediction of anticholinesterase activity and urinary metabolites of isofenphos - use of a percutaneous physiologically-based pharmacokinetic-physiologically-based pharmacodynamic model, J.B. Knaak et al
- analytic solution of a linear physiologically-based pharmacokinetic model prototype useful in risk assessment, Robert N. Brown.
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