書誌事項

Polymeric drugs and drug administration

Raphael M. Ottenbrite, editor

(ACS symposium series, 545)

American Chemical Society, 1994

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注記

"Developed from a symposium sponsored by the Division of Polymer Chemistry, Inc., at the 204th National Meeting of the American Chemical Society, Washington, D.C., August 23-28, 1992."

Includes bibliographical references and indexes

内容説明・目次

内容説明

This work is developed from a symposium sponsored by the Division of Polymer Chemistry Inc, at the 204th National Meeting of the American Chemical Society, Washington DC, August 23-28th, 1992. The book presents advances in polymeric materials designed for controlled drug release; discusses bioelastic characteristics, micelle formation, hydrogels and drug release based on the electric properties of polymers. It also examines polymer-based systems for treatment of inflammatory processes, diabetes, prevention of gastric ulcers, management of central nervous system conditions and in oncology, and describes computer simulations of interactions between polymer matrices and solvents. This book should be of interest to academic and industrial polymer and pharmaceutical chemists, scientists working with drug delivery systems in human and veterinary applications, biochemists, medicinal and clinical chemists.

目次

  • Polymer systems for biomedical applications - an overview, Raphael M. Ottenbrite and Natalya Fadeeva
  • bioelastic materials and the dTt-mechanisms in drug delivery, Dan W. Urry et al
  • sequence-selective binding of DNA by oligopeptides as a novel approach to drug design, Moses Lee and Clint Walker
  • protein device for glucose-sensitive release of insulin, Y. Ito and Y. Imanishi
  • preparation and characterization of enzyme-digestible hydrogels from natural polymers by gamma irradiation, Kalpana R. Kamath and Kinam Park
  • pharmacokinetics and toxicity of a p-boronophenylalanine-cyclodextrin formulation delivered by intravenous infusion to dogs, T.R. LaHann and W.F. Bauer
  • electrorelease of drugs from composite polymer films, Maria Hepel and Zbigniew Fijalek
  • pulsatile drug release by electric stimulus, You Han Bae et al
  • poly(ethylene oxide)-based delivery systems - influence of polymer molecular weight and gel viscoelastic behaviour on drug release mechanism, A. Apicella et al
  • development of micelle-forming polymeric drug with superior anticancer activity, M. Yokoyama et al
  • optimization of poly(maleic acid-alt-2-cyclohexyl-1,3-dioxepin-5-ene) for anti-human immunodeficiency virus activity, Jian Ling Ding and Raphael M. Ottenbrite
  • enhancement of cell membrane affinity and biological activity of polyanionic polymers, Yasuo Suda et al
  • accummulation of poly(vinyl alcohol) at inflammatory site, Tetsuji Yamaoka et al
  • design of new building blocks in resorbable polymers - application in drug delivery microspheres, Ann-Christine Albertsson et al
  • chain structure and hydrolysis of nonalternating polyester amides, Kenneth E. Gonsalves and Xiaomao Chen
  • polymeric site-directed delivery of misoprostol to the stomach, P.W. Collins et al
  • use of a-1,4-polygalactosamine as a carrier of macromolecular prodrug of 5-fluorouracil, Tatsuro Ouchi et al
  • poly(methacrylic acid) hydrogels for rumen bypass and the delivery of oral vaccines to ruminants, T.L. Bowerstock et al
  • polymer-solvent interactions studied with computational chemistry, Samuel J. Lee and Kinam Park.

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