The biology of schizophrenia : proceedings of the 7th International Symposium of the Tokyo Institute of Psychiatry, Tokyo, Japan, October 19-20, 1992



The biology of schizophrenia : proceedings of the 7th International Symposium of the Tokyo Institute of Psychiatry, Tokyo, Japan, October 19-20, 1992

editors, T. Moroji and K. Yamamoto

(Developments in psychiatry, v. 10)

Elsevier, 1994

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Includes bibliographical references



Based on the 7th International Symposium of the Tokyo Institute of Psychiatry, this book covers major world topics in the biological study of schizophrenia. The volume is divided into 4 major sections: the history of the concept of schizophrenia; neuromorphological and brain-imaging studies; psychophysiological findings observed in schizophrenics in connection with genetics, psychology and psychopharmacology; and new research strategies for understanding the pathophysiology of schizophrenia, the biological mechanism underlying the relapse process of schizophrenic symptoms and the differences in pharmacological profiles between typical and atypical neuroleptics.


  • Part 1 Concept of schizophrenia: the concept of schizophrenia and the development of DSM-IV, N.C. Andreasen and M.A. Flaum. Part 2 Brain imaging and morphology: developments in neuroanatomical schizophrenic research - a brief review, B. Bogets
  • exploratory data analysis to identify subtypes of pathophysiology in schizophrenic - support for the coexisting three-syndrome concept, R. Toyoshima et al
  • metabolic imaging in positron emission tomography in schizophrenia, M.S. Buchsbaum et al
  • positron emission tomographic studies on cortical control of saccade in schizophrenia, Y. Nakashima et al
  • simple reaction time and regional cerebral blood flow in patients with schizophrenia, M. Kurachi et al. Part 3 Pathophysiology: the place of psychology in biological studies of schizophrenia, P.S. Holzman
  • smooth pursuit eye movements and control of express saccades in schizophrenic patients, Y. Matsue
  • psychophysiological classifications and syndromes in schizophrenia, J.H. Gruzelier
  • dynamic event-related potential topography in schizophrenia - special reference to P300, C. Ogura and H. Ohta
  • reproduction of psychophysiological signs in animals - implication for a noradrenaline hypothesis of schizophrenia, K. Yamamoto et al. Part 4 Neurochemistry and psychopharmacology: chronic methamphetamine intoxication in monkeys as an animal model of schizophrenia, Y. Machiyama
  • neurotransmitter dysfunctions in schizophrenia, A. Carlsson
  • schizophrenic psychosis - speculative new evidence to support the glutamatergic hypothesis of pathophysiology, C.A. Tamminga et al
  • disturbed neurotransmission via N-methyl-D-aspartate receptor and schizophrenia, T. Nishikawa et al
  • experimental studies of methamphetamine-induced behavioural sensitization as a model of vulnerability to relapse of schizophrenia, K. Akiyama et al
  • a clinical and biochemical model of relapse prediction in schizophrenia - a role for CSF interneukin 2?, D.P. van Kammen et al
  • effects of typical/atypical neuroleptics on the functioning of central dopamine systems - possible relevance of clinical effects, B.S. Bunney
  • preferential dopaminergic activation by clozapine in the medial prefrontal cortex - an in vivo microdialysis study, T. Koyama et al
  • occurrence of neuropeptides and growth factors in relation to mesencephalic dopamine neurons, T. Hukfelt et al
  • cholecystokinin and met-enkephalin in schizophrenic postmortem brains, H. Shibuya and M. Toru
  • possible involvement of mesocortical dopaminergic system in methamphetamine-induced behavioural sensitization - with special reference to the functional relationship of mesocortical dopaminergic system and CCK neurons in the forebrain, T. Moroji et al.

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