Cellular proteolytic systems
Author(s)
Bibliographic Information
Cellular proteolytic systems
（Modern cell biology, v. 15）
Wiley-Liss, 1994
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Includes index
Description and Table of Contents
Description
Cellular Proteolytic Systems Edited by Aaron J. Ciechanover & Alan L. Schwartz Within cells, regulation of protein degradation, or proteolysis, is critical to dynamic control of protein levels. Cellular Proteolytic Systems is the first book to provide a detailed and comprehensive summary of advances in the biochemistry, cellular biology, molecular genetics, and physiology of the major proteolytic processes. The field of cellular proteolysis is advancing rapidly and has great potential impact in a variety of research and clinical areas, including AIDS and cancer research and treatment. The editors, pioneers in the field of cellular and protein research, describe our current understanding of the three major cellular proteolytic systems: the ubiquitin system, the lysosomal and vacuolar systems, and physiological and pathophysiological cellular proteolysis. Individual chapters cover topics from the molecular genetics of the ubiquitin system to regulation of autophagy to antigen processing and presentation. Cellular Proteolytic Systems will provide an excellent foundation in the biological basis of protein turnover for cellular, developmental, and molecular biologists.
Table of Contents
UBIQUITIN SYSTEM. The Ubiquitin-Mediated Proteolytic Pathway: Mechanisms of Recognition of the Proteolytic Substrate and Involvement in the Degradation of Native Cellular Proteins (A. Ciechanover & A. Schwartz). Molecular Genetics of the Ubiquitin System (D. Gonda). LYSOSOMAL/VACUOLAR SYSTEMS. Selective Degradation of Cytosolic Proteins by Lysosomes (J. Dice & S. Terlecky). Autophagy: Its Mechanism and Regulation (G. Mortimore & M. Kadowaki). Hepatic Endosomes Are a Major Physiological Locus of Insulin and Glucagon Degradation In Vivo (F. Authier, et al.). Proteolysis in the Yeast Vacuole (E. Jones & D. Murdock). PROTEOLYSIS IN THE ENDOPLASMIC RETICULUM. Degradation of Proteins Retained in the Endoplasmic Reticulum (J. Bonifacino & R. Klausner). PROTEOLYSIS RELATED TO ANTIGEN PRESENTATION. Protein Catabolism and Antigen Processing (C. Harding). VIRAL-RELATED/HIV PROTEASE. Viral Proteases: Structure and Function (T. Oprea, et al.). Index.
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