Molecular genetics of bacterial pathogenesis : a tribute to Stanley Falkow

書誌事項

Molecular genetics of bacterial pathogenesis : a tribute to Stanley Falkow

editors, Virginia L. Miller ... [et al.]

ASM Press, c1994

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This volume offers a comprehensive overview of the progress in our understanding the microbial pathogenesis of important bacterial pathogens and also offers insights into how these advances have been made via use of recombinant DNA and other molecular techniques. Dr. Stanley Falkow stimulated much of this research through his own work and that of his students. Dr. Falkow's achievements include seminal discoveries on the nature of plasmids and transposons encoding antibiotic resistance, developing the first DNA probes for the diagnosis of bacterial infections, and being one of the first scientists to study the interactions of a wide variety of bacterial pathogens and host cells. The introductory chapters and selections in Part 1 depict the state of the art at the time when Dr. Falkow and his staff first began their investigations in the 1960s, describe how key experiments arose, and give a flavor of the laboratory environment at that time. The 29 chapters in Parts 2 through 6 are topical reviews of key areas of molecular pathogenesis currently under investigation by alumni of the Falkow laboratory. All of the scientists contributing to this book worked in Dr. Falkow's laboratory. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.

目次

  • Part 1 Retrospective look at earlier advances: molecular nature, conjugal transfer and replication of extrachromosomal elements 1961 to 1973
  • R plasmids and antibiotic resistance
  • transposon Tn3, 1973 to 1980
  • enterotoxic escherichia coli, 1971 to 1979
  • molecular epidemiology - development and application of molecular methods to solve infectious disease mysteries. Part 2 Adhesins: adherence mechanisms in urinary tract infections
  • escherichia coli type 1 pili
  • mechanisms of pilus antigenic variation in neisseria gonorrhoea
  • type 4 pili in the families moraxellaceae and neisseriaceae
  • genes for the filamentous haemagglutinin and fimbriae of bordetella pertussis - co-location, co-regulation and co-operation?
  • early events in the pathogenesis of haemophilus influenzae disease
  • molecular pathogenesis of enteropathogenic escherichia coli
  • murine colonic hyperplasia. Part 3 Molecular and cellular biology of intracellular bacteria: genetic approaches to understanding salmonella pathogenicity
  • mechanisms of yersinia entry into mammalian cells
  • cell biology of salmonella pathogenesis
  • intracellular trafficking of legionella pneumophila within phagocytic cells
  • cellular biology of listeria monocytogenes infection
  • determinants of chlamydial pathogenesis and immunity. Part 4 Extracellular structures and products: genetic analysis of the escherichia coli K1 capsule gene cluster
  • type III capsular polysaccharide of group B streptococci - role in virulence and the molecular basis of capsule expression
  • unorthodox secretion by gram-negative bacteria
  • holistic perspective on the escherichia coli haemolysin
  • YOPS of the pathogenic listeria SPP
  • role of flagella in campylobacter pathogenesis
  • molecular biology and role in disease of the vero- (shiga-like) toxins of escherichia coli. Part 5: Virulence gene regulation: co-ordinate regulation of virulence in bordetella pertussis mediated by the vir/bvg locus
  • methylation-dependent and lrp-dependent fimbrial gene regulation in escherichia coli
  • the tao of urease
  • pJM1 plasmid-mediated iron transport-virulence system of vibrio anguillarum. Part 6 Other aspects of bacterial pathogenesis: role of sucrose metabolism in the carcinogenicity of the mutans streptococci
  • how many bacteria does it take to cause diarrhoea and why?
  • genetics as a route toward mucosal vaccine development
  • phylogenetic diversity of microbial pathogens.

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