Proteins, transmitters and synapses


Proteins, transmitters and synapses

David G. Nicholls

Blackwell Scientific Publications, 1994

大学図書館所蔵 件 / 21



Includes bibliographical references and index



This exciting text adopts a modern approach to the understanding of the biochemistry of synaptic function, the primary building block of mind and higher brain processes. The book concentrates on the functioning of the isolated nerve terminal or synaptosome, the simplest model from which the workings of all the important events in neurotransmission can be deduced. Students are provided with a detailed biochemical insight into the mechanism of release of the major class of amino-acid neurotransmitters such as GABA which directly affect the neuronal membrane. Aimed at the advanced undergraduate, and at researchers, this is a clearly expounded, comprehensive and up to date account of the subject.


  • Introduction: principles of neurotransmission
  • Preparations for the study of synaptic biochemistry
  • Ions and membrane potentials
  • The neuronal plasma membrane: transporters, pumps and channels
  • Signal transduction within neurones
  • Sensory receptors
  • Mechanisms of exocytosis
  • Exocytosis of large dense-core vesicles from neurones and secretory cells
  • Amino acids as neurotransmitters
  • Acetylcholine
  • Monoamine and purine neurotransmitters
  • Neuropeptides
  • Molecular aspects of neuronal development and plasticity

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