Experimental and genetic models of hypertension

書誌事項

Experimental and genetic models of hypertension

editors, D. Ganten, W. de Jong

(Handbook of hypertension / series editors: W. H. Birkenhäger and J. L. Reid, v. 16)

Elsevier, 1994

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注記

Includes bibliographies and index

内容説明・目次

内容説明

This volume is a successor to volume focusing on the recent conceptual revolution in fundamental hypertension research. Without neglecting the heritage of earlier achievements, it highlights such brilliant breakthroughs in molecular genetics as the creation of transgenic animals as a source of a new pathogenesis of hypertension. A core of (patho)physiological mechanisms operative in experimental hypertension is provided, including several which act to maintain a normotensive state. The volume provides background and technical information on the use of different models of hypertension in a variety of animal species. A wealth of new information regarding the several different complications observed in genetic and other models of hypertension, as well as new animal models dedicated to these aspects, are also presented. Furthermore, new chapters addressing genotyping and the use of transgenics in hypertension are included. The book should pave the way for students and the beginner in hypertension research, and the experienced researcher who wishes to keep abreast of a rapidly developing field.

目次

  • Blood pressure measurement in rats, R.D. Bunag
  • hemodynamics of the conscious rat, P.B. Persson
  • experimental renovascular hypertension - methodological aspects and role of the renin-angiotensin system, M. Ruzicka and F.H.H. Leenen
  • antihypertensive function of the renal papilla in different models of hypertension, E.E. Muirhead
  • hypertensive models for diabetes, obesity, or aging, R.D. Bunag
  • experimental hypertension following kidney transplantation in the rat, R. Rettig and B. Schmitt
  • genetic hypertension in mice, G. Schlager
  • strategies for the identification of chromosomal loci associated with hypertension in hereditary hypertensive rats, N. Hubner et al
  • the genetics of hypertension in Dahl rats, J.P. Rapp
  • maintenance of hypertensive rats, with special reference to the use of genetic markers for defining rat strains, M.F.W. Festing
  • hypertension in the genetically hypertensive (GH) strain, F.O. Simpson et al
  • the Sabra hypertension-prone and -resistant strains, D. Ben-Ishay and Y. Yagil
  • the Lyon strains of hypertensive, normotensive and low blood pressure rats, M. Vincent and J. Sassard
  • the Milan hypertensive strain - a description of the model, P. Ferrari and G. Bianchi
  • development of the spontaneously hypertensive rat (SHR), the stroke-prone SHR (SHRSP) and their various substrain models for hypertension-related cardiovascular diseases, Y. Yamori
  • pathophysiological aspects of genetically determined hypertension in rats, with special emphasis on stroke-prone spontaneously hypertensive rats, M. Volpe and S. Rubattu
  • the central nervous system and hypertension - the role of catecholamines and neuropeptides, D.H.G. Versteeg et al
  • angiotensin mechanisms in hypertension, C.M. Ferrario et al
  • brain lesions and hypertension, W.T. Talman and D.J. Reis
  • neurogenic hypertension in the rat, K.G. Franchini and E.M. Krieger
  • neurogenic hypertension, M. Weinstock
  • social interaction, salt, and hypertension in mice and rats, J.P. Henry
  • experimental hypertension in the pig, A.F. Dominiczak and D.F. Bohr
  • ACTH-induced hypertension in the sheep - an update, D.G. Parkes et al
  • transgenic animals - new models in hypertension research, M. Paul et al.

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