Mitochondria : DNA, proteins and disease
著者
書誌事項
Mitochondria : DNA, proteins and disease
（Portland Press research monograph, 5）
Portland Press, c1994
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注記
Includes index
内容説明・目次
内容説明
Whilst the basic principles underlying the bioenergetics of mitochondria have been understood for some time, it has only recently become clear that defects in the mitochondrial genome, such as major deletions and point mutations, cause a number of human diseases, chiefly mitochondrial myopathies and encephalopathies, and Leber's hereditary optic neuopathy. This book aims to bridge the gap between basic research and clinical practice by bringing together the genetic and bioenergetics aspects of mitochondrial metabolism. Research workers, clinicians and postgraduate students interested in bioenergetics, reperfusion damage, mitochondrial myopathies and neurodegenerative disorders should find this book of interest.
目次
- Part 1 Mitochondrial structure and function: the proteins of the mitochondrial inner membrane and their role in oxidative phosphorylation, V.M. Darley-Usmar et al
- the structure and organization of the mitochondrial genome, G. Attardi
- transport and processing of mitochondrial proteins, N. Pfanner
- control of mitochondrial metabolism, J. McCormack and R. Denton. Part 2 Experimental models of defects in mitochondrial function: interactions between oxidative stress and calcium overload on mitochondrial function, A. Halestrap
- mitochondrial function in ischaemia/reperfusion in the heart, S. P. Allen and D. Stone
- experimentally induced mitochondrial defects, D. Hayes Part 3 The clinical manifestation of perturbations in mitochondrial biogenesis and function: biochemical aspects of mitochondrial respiratory chain defects, J.M. Cooper and J.B. Clark
- respiratory chain abnormalities in human disease - an overview, A.H.V. Shapira
- defects of beta-oxidation, D. Turnbull
- defects of cytochrome c oxidase, N. Bresolin.
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