Anthracycline antibiotics : new analogues, methods of delivery, and mechanisms of action
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Bibliographic Information
Anthracycline antibiotics : new analogues, methods of delivery, and mechanisms of action
（ACS symposium series, 574）
American Chemical Society, 1995
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"Developed from a symposium sponsored by the Division of Carbohydrate Chemistry at the 205th National Meeting of the American Chemical Society, Denver, Colorado, March 28-April 2, 1993."
Includes bibliographical references and indexes
Description and Table of Contents
Description
Developed from a symposium sponsored by the Division of Carbohydrate Chemistry at the 205th National Meeting of the American Chemical Society, Denver, Colorado March 28-April 2, 1993, this volume covers the synthesis of promising new analogues, and studies structure-activity relationships of anthracycline antibiotics. The book investigates new approaches to improving properties for anthracyclines by using different drug-delivery and tumour-targeting systems. It covers the mechanisms of action of anthracyclines, their interactions with cellular targets, and biological and clinical aspects.
Table of Contents
- Unresolved structure-activity relationships in anthracycline analogue development, Edward M. Acton
- non-cross-resistant anthracyclines with reduced basicity and increased stability of the glycosidic bond, Waldemar Priebe et al
- fluorinated anthracyclines and their glycosylated products, Antonio Guidi et al
- semisynthetic rhomycins and anthracycline prodrugs, C. Kolar
- synthetic options for reversal of anthracycline resistance and cardiotoxicity, Claude Monneret et al
- synthesis and biological activities of fluorinated daunorubicin and doxorubicin analogues, Tsutomu Tsuchiya and Yasushi Takagi
- redox chemistry of anthracyclines and use of oxomorpholinyl radicals, Tad H. Koch and Giorgio Gaudiano
- synthesis of anthraquinone analogues of linked anthracycline, Ping Ge and Richard A. Russell
- synthesis and study of structure-activity relationships of new classes of anthracyclines, Antonino Suarato et al
- molecular recognition of DNA by daunorubicin, Jonathan B. Chaires
- adducts of DNA and anthracycline antibiotics - structures, interactions and activities, J.Y.-T. Wang et al
- DNA topisomerases and their inhibition by anthracyclines, Yves Pommier
- anthracycline antihelicase action - new mechanism with implications for guanosine-cytidine intercalation specificity, Nicholas R. Bachur et al
- membrane biophysical parameters influencing anthracycline action, Ratna Mehta and Thomas G. Burke
- signal transduction systems in doxorubicin hydrochloride mechamism of action, Paul Vichi et al. (Part contents)
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