Carbohydrate modifications in antisense research

著者

• Sanghvi, Yogesh S.
• Cook, P. Dan
• American Chemical Society. Division of Carbohydrate Chemistry
• American Chemical Society. Meeting

書誌事項

Carbohydrate modifications in antisense research

Yogesh S. Sanghvi, P. Dan Cook

（ACS symposium series, 580）

American Chemical Society, 1994

注記

"Developed from a symposium sponsred by the Division of Carbohydrate Chemistry at the 207th National Meeting of the American Chemical Society, San Diego, California, March 13-18, 1994."

Includes bibliographical references and index

内容説明・目次

内容説明

Reviews recent developments and progress in the carbohydrate-related chemistry of novel nucleic acid mimics and their applications in antisense therapeutics. Discusses the use of new chemical classes to rationally design and synthesize oligonucleotides. Explores several carbohydrate modifications of the oligonucleotide to stabilize against nuclease degradation and to enhance the binding affinity for a given target. Suggests future directions of carbohydrate-related modifications for antisense molecules.

目次

• Carbohydrates: Synthetic Methods and Applications in Antisense Therapeutics: An Overview
• Novel Backbone Replacements for Oligonucleotides
• Synthesis of Nonionic Oligonucleotide Analogues
• Synthesis and Hybridization Properties of DNA Oligomers Containing Sulfide-Linked Dinucleosides
• 4'-Thio-RNA: A Novel Class of Sugar-Modified *b-RNA
• Hexopyranosyl-Like Oligonucleotides
• *a-Bicyclo-DNA: Synthesis, Characterization, and Pairing Properties of *a-DNA-Analogues with Restricted Conformational Flexibility in the Sugar-Phosphate Backbone
• 2#',5#'-Oligoadenylate Antisense Chimeras for Targeted Ablation of RNA
• Branched Nucleic Acids: Synthesis and Biological Applications
• Anti-Human Immunodeficiency Virus Activity and Mechanisms of Unmodified and Modified Antisense Oligonucleotides
• Carboranyl Oligonucleotides for Antisense Technology and Boron Neutron Capture Therapy of Cancers
• Advances in Automated Chemical Synthesis of Oligoribonucleotides
• Anti-Human Immunodeficiency Virus Activity of a Novel Class of Thiopurine-Based Oligonucleotides
• New Twists on Nucleic Acids: Structural Properties of Modified Nucleosides Incorporated into Oligonucleotides

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BA24328158
• ISBN:
  • 0841230560
• LCCN: 94038930
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Washington, DC
• ページ数/冊数: viii, 232 p.: ill.
• 大きさ: 24cm
• 分類:
  • LCC : QP623.5.A58
  • DC20 : 547.7/9
• 件名:
  • LCSH : Antisense nucleic acids -- Congresses
  • LCSH : Oligonucleotides -- Derivatives -- Congresses
  • LCSH : Carbohydrates -- Congresses
• 親書誌ID:
  • BA00073096