Bioactive secondary metabolite of microorganisms
Author(s)
Bibliographic Information
Bioactive secondary metabolite of microorganisms
（Progress in industrial microbiology, v. 30）
Elsevier, 1994
- : Ister Science
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
This illustrated book covers the most important aspects concerned with microbial bioactive secondary metabolites and provides basic information on their biosynthetic pathways in relation to growth and differentiation of their producers, as well as information on the physiological and genetic regulation of their production. Further, the best-known and most important secondary microbial metabolites are discussed, and data on structure-bioactivity relationships, mechanisms of action, and the biochemical and genetic basis of resistance are also included. The greatest potential use of this book would be as a starting point from which one could be directed to other sources if more details were necessary. It is mainly intended for students and researchers in the fields of microbiology, biochemistry, chemistry of natural organic compounds, toxicology, pharmacology, human and veterinary medicine or environmental sciences.
Table of Contents
Part 1 Microbial Primary and Secondary Metabolism: Definitions. Primary and secondary metabolism. Interconnections between primary and secondary metabolism. Speculations on the function of secondary metabolites. Part 2 Secondary Biosynthetic Pathways: Secondary metabolites derived from saccharides. Polyketide-derived secondary metabolites. The terpenoid route. Macrocyclic lactones. Shikimate pathway metabolites. Metabolites derived from amino acids. Part 3 Secondary Metabolism in Relation to Growth and Differentiation: Biosynthesis of secondary metabolites and growth. Bacterial differentiation and secondary metabolism. Secondary metabolism and differentiation in actinomycetes. Fungal differentiation and secondary metabolism. Part 4 Physiological Regulation of Secondary Metabolism: Regulation of branching pathways. Induction of secondary metabolic pathways. Feedback regulation in secondary metabolite biosynthesis. Catabolite regulation. Part 5 Genetic Regulation of Secondary Metabolism: Mutation and selection of high-producing mutants. Molecular genetics of polyketides. Genetics of ribosomally synthesised peptides. Genetics of autoregulatory factors in actinomycetes. Part 6 Antibiotics: Sources of antibiotics. Chemical classification of antibiotics. Part 7 Enzyme Inhibitors: Inhibitors of proteinases. Inhibitors of glycosidases. Inhibitors of other hydrolases. Inhibitors of oxidoreductases. Inhibitors of transferases. Inhibitors of lyases. Therapeutic applications of enzyme inhibitors. Part 8 Alkaloids: Ergot alkaloids. Psilocybin and psilocin. Cycloplazonic acid and cyclopenin-viridicatin group. Part 9 Bacterial Toxins and Phycotoxins: Bacterial exotoxins and endotoxins. Use of bacterial neurotoxins in medicine. Insecticidal toxins of bacteria. Phycotoxins. Mycotoxins. Aflatoxins. Citrinin. Anthraquinones. Miscellaneous mycotoxins. Part 10 Microbial Metabolites Affecting Plant Growth and Metabolism: Gibberellins. Phytotoxins. Antibiotics and microbial herbicides. Phytoalexins, plant defence metabolites. Part 11 Antiparasitic and Growth Promoting Agents: Microbial insecticides and miticides. Antibiotics against phytopathogenic microorganisms. Antiparasitic and growth promoting agents. Part 12 Pharmacologically Interesting Agents: Antitumour and antiviral antibiotics. Immunomodulators. Metabolites with miscellaneous pharmacological effects. Part 13 Structure-Activity Relationships: Structural features of bioactivity. Lincomycins. Polyene antibiotics. Small Lactones. Part 13 Mechanisms of Action of Antibiotics and Mycotoxins: Biochemical targets for drug action. Inhibitors of cell-wall biosynthesis. Drugs affecting functions of cell membranes. Inhibitors of energy metabolism. Part 14 Mechanisms of Resistance to Antibiotics: Biochemical basis of antibiotic resistance. Genetic basis of antibiotic resistance. Self-protection mechanisms in antibiotic producers. (Part contents).
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