Biofluid and tissue analysis for drugs, including hypolipidaemics

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書誌事項

Biofluid and tissue analysis for drugs, including hypolipidaemics

edited by Eric Reid, Howard M. Hill, Ian D. Wilson

（Methodological surveys in bioanalysis of drugs, v. 23）（Special publication / Royal Society of Chemistry, no. 155）

Royal Society of Chemistry, c1994

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注記

"Based on the proceedings of the Tenth International Forum entitled Biofluid and Tissue Analysis for Drugs, including Hypolipidaemics, held on the 7-10 September 1993, in Guildford, UK"--T.p. verso

内容説明・目次

内容説明

Integrated and user-friendly, Biofluid and Tissue Analysis for Drugs, Including Hypolipidaemics, reviews drug development methodology and associated problems with particular reference to the analysis of biofluids and tissues. As with other volumes in this series, this book describes the state of the art in bioanalysis of drugs. A special feature is the unique section that provides the bioanalytical spectrum for lipid-lowering (hypolipidaemic) drugs, with stratagems and practical points that have applicability to other drug types, and wider implications. Biofluid and Tissue Analysis for Drugs, Including Hypolipidaemics gives novel guidance for the training of company recruits, and has an international spread of authors. Its breadth of coverage makes it an obvious choice for library shelves within industrial and professional organizations, and its practical information will be valued by laboratory staff involved in drug metabolism studies and associated bioanalytical research.

目次

  • Initiating the novice: bioanalytical baptism: Education and within company training
  • Sample clean-up `primer'
  • Ways to meet some analytical aims: HPLC-NMR for metabolite study
  • Bioanalytical capillary electrophoresis
  • Hypolipidaemic agents: Background
  • Assay surveys
  • Fibrate metabolites
  • `Statin' drugs
  • Various analytes in biofluids and tissues: A `case history'
  • On-line sample dialysis
  • Diverse drugs, exemplifying problems
  • Assay compendium
  • Biofluid-to-column pathways and pitfalls: Sample preparation: automation
  • SPE expert system
  • Troubles from interferants, haemolysis, instability and adsorption
  • Microdialysis
  • Analyte Index
  • General Index.

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