CiNii Books - Cancer therapy with radiolabeled antibodies

Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.

Table of Contents

Introduction, D.M. Goldenberg Radiobiology, Radiation Physics, and Dosimetry Medical Internal Dosimetry for High-Dose Radionuclide Therapies, D.R. Fisher Radiolabeled Antibody Tumor Dosimetry, D.J. Buchsbaum and B.W. Wessels Radiobiology and Radioimmunotherapy: Implications for Clinical Applications, J.R. Williams, R.R. Mayer, Y. Zhang, S.M. Quadri, and L.E. Dillehay Radiochemistry of Therapeutic Radionuclides Radiochemistry of Therapeutic Radionuclides, G.L. Griffiths Advanced Methods for Rabiolabeling Monoclonal Antibodies with Therapeutic Radionuclides, O.A. Gansow and C. Wu Antibody Radiolabeling with Isotopes of Rhenium, G.L. Griffiths Targeting, Pharmacokinetics, and Experimental Radioimmunotherapy Pharmacokinetics of Antibodies and Their Radiolabels, M.J. Mattes Development of Cancer Radioimmunotherapy and Its Potential Use as an Adjuvant Treatment, R.M. Sharkey, R.D. Blumenthal, and D.M. Goldenberg Experimental Radioimmunotherapy and Methods to Increase Therapeutic Efficacy, D.J. Buchsbaum Clinical Radioimmunotherapy Overview of Obstacles and Opportunities for Radioimmunotherapy of Cancer, G.L. DeNardo and S.J. DeNardo Radioimmunotherapy of Ovarian Cancer, A. Maraveyas and A.A. Epenetos Radioimmunotherapy of Colorectal Cancer, J.L. Murray Radioimmunotherapy in the Treatment of Metastatic Breast Cancer: An Overview, S.J. DeNardo Radioimmunotherapy of CNS Malignant Gliomas by Direct Intralesional Injection of Specific 131I Radiolabeled Monoclonal Antibodies, P. Riva, A. Arista, C. Sturiale, V. Tison, M. Frattarelli, S. Lazzari, G. Moscatelli, G. Franceschi, A. Spinelli, G. Sarti, M. Casi, N. Riva, and F. Campori Treatment of B-Lymphocyte Malignancies with 131I-Lym-1 and 67Cu-2IT-BAT-Lym-1 and Opportunities for Improvement, G.L. DeNardo and S.J. DeNardo Treatment of Relapsed B Cell Lymphomas with High-Dose Radioimmunotherapy and Bone Marrow Transplantation, O.W. Press, J.F. Eary, F.R. Appelbaum, and I.D. Bernstein New Strategies Clinical Application of the Avidin-Biotin System for Tumor Targeting, G. Paganelli, P. Magnani, A.G. Siccardi, and F. Fazio Humanization of Monoclonal Antibodies: Molecular Approaches and Applications, A.S. Dion Human Monoclonal Antibodies: Application in Radioimmunotherapy, J.L. Klein, R.L. DeJager, J.C.J. Stiekeme, M.V. Haspel, N.P. Pomato, R. Subramanian, and M.G. Hanna, Jr. Cytokine-Based Modalities to Enhance Monoclonal-Antibody-Mediated Tumor Cell Killing, J.W. Greiner, S. Shimada, F. Guadagni, C.D. Ullmann, C. Nieroda, and J. Schlom Overcoming Dose-Limiting, Antibody-Induced Myelotoxicity, R.D. Blumenthal, R.M. Sharkey, and D.M. Goldenberg Index

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Cancer therapy with radiolabeled antibodies

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