Advances in drug delivery systems, 5 : proceedings of the Fifth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 25-28, 1991
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書誌事項
Advances in drug delivery systems, 5 : proceedings of the Fifth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 25-28, 1991
Elsevier, 1992
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Includes index
内容説明・目次
内容説明
Can improved delivery systems for vaccines be developed? Can oral delivery of peptides or proteins be achieved? Can clinically useful triggered drug delivery systems be developed? Can active drug targeting with microparticulates be achieved? Can cellular or viral delivery systems be designed? These questions stimulated discussion of recent advances and state of the art technology in drug delivery systems in this Fifth International Symposium. Significant advances have been made since the first meeting in 1983. Passive diffusion-based systems from before that time have evolved to dynamic interactive systems recognizing and responding to physiological and biochemical processes. The thirty papers in this volume represent recent research efforts considered to be important to the future development of drug delivery systems. Six major areas of the science and technology of drug delivery systems are covered: immunotherapeutic; oral delivery; triggered and modulated drug delivery systems; targeting and membrane recognition; new delivery systems; and clinical aspects of drug delivery systems.
目次
Preface (J.M. Anderson et al.). Introductory Remarks (J.A. Mollica). Immunotherapeutics: Synthetic peptides as the basis for vaccines against influenza virus and bacterial toxins (R. Arnon). CD4-HIV-1 interactions: implications for drug delivery (T.K. Hart et al.). Antibody-targeted cyclosporin A (B. Rihova et al.). Enhanced photodynamic killing of target cells by either monoclonal antibody or low density lipoprotein mediated delivery systems (F.N. Jiang et al.). Synthesis and biodistribution of immunoconjugates of a human IgM and polymeric drug carriers (C.J.T. Hoes et al.). Oral delivery: Buccal and colonic absorption of CGS 16617, a novel ACE inhibitor (E. Quadros et al.). The relationship between peptide structure and transport across epithelial cell monolayers (P.S. Burton et al.). Insulin stabilization and GI absorption (L. Hovgaard et al.). Drug glycosides in oral colon-specific drug delivery (D.R. Friend et al.). Polymers for colon-specific drug delivery (J. Kopecek, et al.). In vitro and in vivo studies of enzyme-digestible hydrogels for oral drug delivery (W.S.W. Shalaby et al.). Triggered and modulated drug delivery systems: Development of a morphine-triggered naltrexone delivery system (K.V. Roskos et al.). A novel drug delivery system utilizing a glucose responsive polymer complex between poly [vinyl alcohol] and poly [ N -vinyl-2-pyrrolidone] with a phenylboronic acid moiety (S. Kitano et al.). Controlled release of amylase from a thermal and pH-sensitive, macroporous hydrogel (L.-c. Dong et al.). Trials of lipid modification of peptide hormones for intestinal delivery (S. Muranishi et al.). Blends of PVA and PGLA: control of the permeability and degradability of hydrogels by blending (C.G. Pitt et al.). Targeting and membrane recognition: Modeling membrane targeting: interaction and recognition of proteins with model biomembrane systems (D.W. Grainger et al.). Approaches toward the optimization of CNS uptake of anti-AIDS agents (B.D. Anderson et al.). Carrier design: cytotoxicity and immunogenicity of synthetic branched polypeptides with poly[ L -lysine] backbone (F. Hudecz et al.). Preparation and characterization of a water soluble dextran immunoconjugate of doxorubicin and the monoclonal antibody [ABL 364] (Z. Brich et al.). Intracellular targeting of antibiotics by means of biodegradable nanoparticles (P. Couvreur et al.). New delivery systems: Targeted delivery of DNA by liposomes and polymers (X. Zhou et al.). Bioadhesive liposomes as topical drug delivery systems: molecular and cellular studies (R. Margalit et al.). Controlled release using microencapsulated mammalian cells (M.V. Sefton et al.). Clinical aspects: Biocompatibility studies of naltrexone sustained release formulations (K. Yamaguchi et al.). The tumor blood vessel as an ideal target for macromolecular anticancer agents (H. Maeda).
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