Developmental mechanisms of heart disease
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書誌事項
Developmental mechanisms of heart disease
Futura Pub., c1995
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注記
Papers based on several symposiums on etiology and morphogenesis of congenital heart disease, held in 1978, 1983, 1988, and 1993
Includes bibliographical references and index
内容説明・目次
内容説明
Congenital cardiovascular malformations remain the single largest cause of infant mortality in the industrialized world. Current information indicates that the answer lies in prevention of congenital defects based on an understanding of their etiology and pathogenesis. This book represents a major contribution to the achievement of this goal. In addition to a discussion of cutting edge advances and anticipated directions of new research, each chapter provides an overview of a particular area in this field. While the text facilitates the integration of basic science information for its use in the clinical setting, it will also serve as an excellent reference source for the field of cardiogenesis. Each chapter provides an overview of a particular area. For the clinician, the book introduces the basic concepts and tools and explores the application of these techniques in the patient population. For the basic scientists, this book serves as a resource for the rapidly growing field of cardiogenisis, reviews the clinical spectrum of disease, and targets research areas that currently commcnd intensive investigation.
目次
- Introduction: Developmental Cardiology Comes of Age
- Section I Molecular Biology: Overview: Molecular Analysis of Cardiac Developmental Phenotypes: Problems, Progress and Prospects
- Retinoblastoma Pocket Proteins and the Terminally Differentiated State of Muscle Cells
- Regulation of Cardiomyogenic Differentiation and Divsification
- Positive and Negative Promoter Elements Regulating @-Smooth Muscle Actin Gene Expression in Embryonic Cardiac Myocytes
- The Role of Serum Response Factor, Ying Yang One, and Basic-Helix Loop-Helix Factors on @-Actin Gene Expression During Early Cardiac and Skeletal Muscle Development
- Expression of Troponin C and I Genes Analyzed at the mRNA and Protein Levels in Developing Muscles
- Cardiac-Specific Homebox-Containing Gene of the Mouse
- Section II Clinical Molecular Biology: Overview: Application of Molecular Biology to Medical Genetics
- Genetic Analysis of Hypertrophic Cardiomyopathy in Japan
- Biochemical and Molecular Characterization of X-Linked Dilated Cardiomyopathy
- Morphometric Study on the Development of Right Ventricular Hypetrophy with Age in Congenitally Malformed Hearts
- Expression of Myosin Heavy Chain Genes of Muscle in Various Blood Vessels and Organs
- Changes in Myosin Heavy Chain Gene Expression of Rabbit Ductus Arteriosus Smooth Muscle During Development and Exposure of Cyclic Adenosine Monophosphate
- Section III Cardiogenesis: Overview: Formation and Early Morphogenesis of the Primary Heart Tube
- Overview: Cardiac Morphogenesis
- Overview: Proper Laboratory Practice in Experimental Studies of Abnormal Cardiovascular Development
- Overview: Extracellular Matrix, Receptors, and Heart Development
- Molecular Basis for the Segmental Pattern of Cardiac Cushion Mesenchyme Formation: Role of ES/130 in the Emryonic Chick Heart
- Effect of Endoderm and Growth Factors on the Differentiation of Chick Precardiac Mesoderm in Vitro
- Interactions Between Cardiac Mesenchymal Cells and the Extracellular Matrix in Rat and Chick in Vitro
- Immunohistochemical Localization of Platelet-Derived Growth Factor (PDGF) During Cardiac Morphogenesis in Chick and Mouse Embryos and Fetuses
- Regulation of Early HeartDevelopment by the Fibroblast Growth Factor-2 System
- A Preview of the Molecular Basis for Neural Crest Contribution to Heart Development
- The Conotruncus and Its Septation at the Advert of the Molecular Biology Era
- Normal and Abnormal Morphogenesis of the Outflow Tract
- Development of the Atrail Septal Complex in the Human Heart: Contribution of Spina Vestibuli
- Topography of Cardiac Gene Expression in the Embryo: From Pattern to Function
- Organization and Function of Early Specilized Myocardium
- Maternal Effect on the Cardiac Development of Thp Mouse Fetuses: Enlarged Heart and Malformations
- Vasculogenesis in the Embryo
- Coronary Artery Development and Neural Crest
- Distribution of Cardiac Neural Crest Cells, Fibronectin, and Tenascin in the Outflow Tract of Chick Embryos at Incubation Day 5
- Late Fetal Development of Retinoic Acid-Induced Transposition of Great Arteries: Morphology, Physiology, and Biochemistry
- Asymmetry of the Inferior and Superior Atrioventricular Endocardial Cushions
- Molecular Mechanisms of Complete Transposition of the Great Arteries Produced by All-Trans Retinoic Acid in Mouse Embryo
- Development of the Rat Conduction System as Determined by Leu-7 Immunohistochemistry and Scanning Electron Microscopy
- Three-Dimensional Reconstruction of HNK-1 Immunoreativity in the Embryonic Rat Heart: Codistribution with Early Cardiac Conduction Tissue
- HNK-1 and Actylcholinesterase in the Prenatal Rat Heart and Early Development of Cardiac Conduction Tissue
- Comparison Between Normal and Teratogen-Treated Rat Embryonic Heart Tissue reactivity with Lectin Staining
- Origin of the Orifice of the Pulmonary Vein in the Mouse
- Cardiovascular Anomalies Induced by Small Dose of Bis-Diamine An Animal Model of CATCH 22
- Bis-Diamine-Induced Atrioventricular Septal Defect in Mouse and Rat Fetuses
- Cardiovascular Malformation and Functional Changes Induced by Trichloroethylene in Developing Chick Embryos
- Section IV Functional Development of The Heart: Overview: Functional Maturation and Coupling of the Embryonic Cardiovascular System
- Overview: Biomechanics of Cardiac Development
- Overview: Modeling and Control of Embryonic Hemodynamics
- Functional Characteristics of the Embryonic Heart
- Expression and Functional Activity of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger During Perinatal Development
- Developmental Changes in the Contraction System of Rabbit Arterial Smooth Muscle
- Development of the Blood Outflow Pattern in the Rat Embryo Heart Analyzed by a High-Speed Video Camera: Presence of a Primitive Anterior Systemic Channel
- Mechanical Properties of Rabbit Ductus Arteriosus
- Three-Dimensional Observation of F-Actin and Expression of N-Cadherin and Fibronectin During Cardiac Looping of th eChick Embryo Using CLSM
- Actin Bundle and Cardiac Loop Formation in Chick Embryos
- Section V Human and Animal Models of Cardiac Defects: Overview: Heart Malformation: The Human Model
- Breaking Symmetry: Left-Right Cardiac Development in Xenopus Laevis
- Molecular Analysis of the inv Insertional Mutation
- Deciphering the Lateralization Process or a Way to Understand Congenital Heart Defects
- Atrioventircular Endocardial Cushion in the Pathogenesis of Common Atrioventricular Canal: Morphological Study in the iv/iv Mouse
- Morphology of th Embryonic Atrial Chambers in the Mouse with iv/iv Mutation
- Conotruncal Anomaly Face Syndrome
- The Clinical Significance of 22qll. 2 Deletion
- Detection of 22qll Deletion in Patients with Conotruncal Cardiac Malformations, DiGeorge, Velocardiofacial, and Conotruncal Anomaly Face Syndromes
- CATCH 22: Can Molecular Genetics Explain the Phenotype?
- Molecular and Stochastic Basis of Congenital Heart Disease in Down Syndrome
- WKY/NCrj Strain of the Rate: A New Genetic Animal Model of Congenital Heart Disease
- Abnormalities of Branchial Organs in 45X Fetuses
- Common Atrioventricular Canal and Conotruncal Anomalies in Mice with Heterotaxia
- Morphological Study of the inv Situs Inversus Mutant Mouse
- Animal Models of Visceroatrial Heterotaxy Syndrome in Rodents
- Section VI Epidemiology: Overview: The Epidemiologic Approach to the Study of Congenital Cardiovascualr Malformations
- Transposition of the Great Arteries: Etiologic Distinctions of Outflow Tract Defects in a Case-Control Study of Risk Factors
- EUROCAT Subproject onEpidemiology of Congenital Heart Disease: First Analysis of the Completed Study
- Index
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