Lipid-soluble antioxidants : biochemistry and clinical applications
著者
書誌事項
Lipid-soluble antioxidants : biochemistry and clinical applications
(Molecular and cell biology updates)
Birkhäuser Verlag, c1992
大学図書館所蔵 全5件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Based on a conference, 19-22 Sept. 1991, in Penang, Malaysia
Includes bibliographical references and index
内容説明・目次
内容説明
Antioxidants inhibit the formation and spread of free radicals which can be damaging in biological systems. Free radicals form in biological systems through metabolism, but it is also realized that exogenous environmental sources, such as radiation, food, and drugs, contribute significantly to the generation of free radicals in biological systems. Being reactive species, free radicals are short-lived and do not travel far from cellular targets. Their concentration in biological systems is very low and is difficult to detect directly by electron spin resonance spectroscopy (ESR). Indirect methods of reactions of radicals with specific biomolecules are also sufficiently sensitive to detect quantitatively their presence. Thus the response of antioxidant defenses which react with radical species, can serve as an indirect measure that free radicals have been formed. Redox-based antioxidants change their oxidation state and antioxidants become free radicals themselves. Often, however, the antioxidants give rise to more persistent free radicals, sometimes owing to delocalization of the lone electron around ring structures (in vitamin E, ubiquinones, and certain carotenes).
Persistent free radicals react only rarely and the precursors often can be regenerated in biological systems. In recent years, it is becoming clearer from biochemical studies on how the major lipophilic antioxidants work. Particular attention has been given to vitamin E and quinones found in animal and plant membranes and in carotenoids, for the protection of membranes in lipoprotein systems. Flavonoids form another rich and varied source of natural antioxidants.
目次
Vitamin E: Tocopherols and Tocotrienols and Ubiquinones.- New horizons in vitamin E research - The vitamin E cycle, biochemistry, and clinical applications.- The reactivity of tocotrienols and other lipid-soluble antioxidants towards peroxyl radicals.- Physical/chemical studies of vitamin E in membranes.- Synergistic effect of lipid hydroperoxyl radical scavenging and lipid hydroperoxide reduction in the inhibition of lipid peroxidation in biomembranes.- Determination of rate constants for antioxidant activity and use of the crocin assay.- Vitamin E in protection of oxidative impairment in endothelial and platelet functions.- Antioxidant effectiveness of tocopherol isomers.- Effect of vitamin E on metabolism of uremic low density lipoproteins in human monocyte-derived macrophage.- Difference of antioxidative effect between vitamin E and selenium.- Tocopherol and tocotrienol plasma transport and tissue concentrations: Implications for their relative biological functions.- Modulation of cell proliferation by tocopherols and tocotrienols: Role in arteriosclerosis.- Vitamin E and health in the marmoset monkey: A non-human primate model for nutritional research.- Antitumor and antioxidant activity of tocotrienols.- Tocopherols, carotenoids and the glutathione system.- Nutrition of tocotrienols and lipid metabolism.- Carotenoids, Flavonoids and Retinoids.- Carotenoids and vitamin A: An overview.- Metabolism of carotenoids by enzymes of oxygen metabolism.- Role of ?-carotene in disease prevention with special reference to cancer.- Anti-tumor and anti-tumor promoting activity of ?- and ?-carotene.- Production of palm oil carotenoid concentrate and its potential application in nutrition.- Carotenoids, novel polyene polyketones and new capsorubin isomers as efficient quenchers of singlet molecular oxygen.- Modification of alloxan diabetes in rats by vitamin A status.- Flavonoids in foods: Their significance for nutrition and health.- Studies on flavonoids and related compounds as antioxidants in food.- Autocoid-immunopharmacology of flavonoids.- Anticarcinogenicity of flavonoids as studied by inhibition of lipid peroxidation, microsomal degranulation and their interactions with benzo(a)pyrene metabolites.- Role of retinoids in modulating the molecular actions of environmental carcinogens.- Parasitic and Infectious Diseases.- Free radicals and antioxidants in malaria.- Oxygen free radicals in malaria.- The mechanism of antimalarial action of artemisinin (Qinghaosu).- Erythrocytic GSH level and stability in Plasmodium vivax malaria.- Plasma lipid peroxidation in P. falciparum malaria.- Presence, formation and function of ubiquinones Q6 and Q8 in filarial parasites.- Catalase activity in red cell and liver of mice infected with Plasmodium berghei.- Clinical Applications. Antioxidant Therapy.- The hypolipidaemic effect of different diets.- Epidemiological correlations between poor plasma levels of essential antioxidants and the risk of coronary heart disease and cancer.- Effect of different antioxidants in experimental myocardial infarction.- Lipid-soluble plant phenols as antioxidants and anti-mutagens.- Anti-cancer effects of cis-unsaturated fatty acids both in vitro and in vivo.- Clinical studies on polyunsaturated fatty acids and antioxidants in African children.- Dihydrolipoic acid is protective against reperfusion injury.- Effect of japanese herbal medicine, Sho-saiko-to-go-keishi-kashakuyaku-to (TJ-960) on aging.- Lipoprotein oxidation.- Hepatic lipid peroxidation in ethanol potentiated aflatoxin B1 hepatotoxicity.- Palm oil vitamin E effects in hypercholesterolemia.- Fat soluble antioxidant vitamins in cancer patients.- Butylated hydroxytoluene toxicity.- Effects of tocotrienols-rich vitamin E on patients with peripheral vascular disease.- Protection from air pollution injury by dietary vitamin E.
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