Research advances in Alzheimer's disease and related disorders
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Bibliographic Information
Research advances in Alzheimer's disease and related disorders
Wiley, c1995
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Contains selected papers presented at the Fourth International Conference on Alzheimer's Disease and Related Disorders, held in Minneapolis, Minn., July 29 to Aug. 3, 1994
Includes bibliographical references and index
Description and Table of Contents
Description
Following a long period of comparative neglect, Alzheimer's disease has come to be a major focus of scientific research, and in recent years considerable progress has been made towards understanding the basic molecular mechanisms of the disease and toward developing diagnostic and therapeutic strategies. Here, the latest information on Alzheimer's disease is presented, including topics such as the mechanisms of degeneration of neurons with neurofibrillary tangles, the formation of brain amyloid in Alzheimer's disease, risk factors, diagnosis and pharmacological approaches. The chapters are of a high standard, reflecting the fact that the authors are internationally renowned in their own specialist field and the book will have a wide appeal to psychopharmacologists, neurologists, psychiatrists, neurobiologists and neurochemists who seek a broad overview of the present thinking in the field.
Table of Contents
Partial table of contents: EPIDEMIOLOGY. The Epidemiology of Alzheimer's Disease: Beyond Risk Factors (J. Mortimer). GENETICS. Apolipoprotein E and Alzheimer's Disease (A. Roses, et al.). DIAGNOSIS. Impaired Vasodilation of Skin Vessels in Alzheimer's Disease (A. Algotsson, et al.). CLINICAL COURSE. Behavioral Changes in Early Alzheimer's Disease (L. Harrell, et al.). TREATMENT STRATEGIES. Drug Development must be Optimized in Order to Choose the Correct Strategy (N. Cutler & J. Sramek). NEUROPATHOLOGY. The Pathological Lesions of Alzheimer's Disease: Form and Formation (D. Mann). CYTOSKELETAL PATHOLOGY. What have we Learned from Paired Helical Filaments? (Y. Ihara). AMLOIDOGENESIS. Amyloids, Genes and Chaperons in Alzheimer's Disease (B. Frangione, et al.). APP BIOLOGY. Biological Function and Processing of APP (N. Robakis, et al.). MODEL SYSTEMS. Fibrillar and Non-Fibrallar Amyloid in the Brain of Aged Dogs (F. Wegiel, et al.). PRION DISEASES. Molecular Biology, Genetics and Protein Chemistry of Prion Disease (M. Baldwin & S. Prusiner). Index.
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