Proceedings of the Thirty-fifth Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues held at Indiana University of Medicine Indianapolis, Indiana October 3 and 4, 1994
著者
書誌事項
Proceedings of the Thirty-fifth Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues held at Indiana University of Medicine Indianapolis, Indiana October 3 and 4, 1994
（Advances in enzyme regulation, v. 35）
Pergamon Press, c1995
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This internationally acclaimed annual series reports progress at the cutting edge in the strategic area of regulation at the molecular level. In an integrated presentation of original papers, leading scientists, Nobel Prize winners and other experts from many countries review the best research produced each year and evaluate what is newest and what promises to be the most important in clinical and basic investigations. The volumes serve as guideposts and beacons for investigators in planning research and teaching students in basic and clinical fields of endeavour. These books aim to advance the general front of studies on metabolic regulation and the understanding of the molecular biology of control of gene expression by hormones, drugs and growth factors in cancer cells and in clinical situations of diabetes, inborn errors of metabolism and neoplasia. This book is aimed at basic scientists and clinicians interested in metabolic regulation, chemotherapy resistance, enzymic targeting and the role of oncogenes.
目次
- Part 1 Regulation through signal transduction: regulation of signal transduction, G. Weber et al
- nuclear inositol lipid cycle and differentiation, L. Cocco et al. Part 2 Control through oncogenes: regulation of c-myb expression in ML-1 human myeloblastic leukemia cells by C-ets-1 protein, A. Bloch et al
- isolation and biological activities of signal transduction inhibitors from microorganisms and plants, K. Umezawa. Part 3 Regulation of enzymes of DNA biosynthesis: structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo, J.G. Cory et al
- human thymidine kinase 1 - regulation in normal and malignant cells, B. Munch-Petersen. Part 4 Tumour metabolism and chemotherapy: glucuronidation by human colorectal adenocarcinoma cells as a mechanism of resistance to mycophenolic acid, T.J. Franklin et al
- tumor metabolism - the lessons of magnetic resonance spectroscopy, M. Stubbs et al
- preferential kill of hypoxic EMT6 mammary tumor cells by the bioreductive alkylating agent porfiromycin, A.C. Sartorelli et al. Part 5 Hormonal and dietary regulation: hormonal control of hepatic glutaminase, J.T. Brosnan et al
- a new family of protein kinases - the mitochondrial protein kinases, R.A. Harris et al. Part 6 Regulation of lipolysis: co-ordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo - implications for the control of fat storage and fat mobilization, K.N. Frayn et al
- intracellular triacylglycerol lipase - its role in the assembly of hepatic very-low-density lipoprotein (VLDL), G.F. Gibbons and D. Wiggins. Part 7 Regulation by phosphorylation and feedback: microfilament dynamics - regulation of actin polymerization by actin-fragmin kinase and phosphatases, E. Waelkens et al
- mammalian phosphoribosylpyrophosphate synthetase, M. Tatibana et al. Part 8 Control by methylation and through matrix enzymes: thiopurine induced disturbance of DNA methylation in human malignant cells, R. De Abreu et al
- topoisomerase II isozymes involved in anticancer drug action and resistance, D.J. Fernandes et al. Part 9 Metalloproteinase and secretory vesicles: sorting and budding of constitutive secretory vesicles in hepatocytes and hepatoma cells, A. Barthel et al
- matrix metalloproteinase inhibitors - a novel class of anticancer agents, P.D. Brown. Part 10 Special symposium lecture: compartmentalization of cyclic AMP phosphodiesterases, signalling "crosstalk", desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP, M.D. Houslay. (Part Contents).
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