Dialysis-related amyloidosis : international symposium, Nagoya, May 28-29, 1994
著者
書誌事項
Dialysis-related amyloidosis : international symposium, Nagoya, May 28-29, 1994
（Contributions to nephrology, v. 112）
Karger, 1995
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Dialysis-related amyloidosis is a freequent complication encountered in patients receiving long-term haemodialysis. This book presents evidence on the possible role of beta2-microglobulin modified with advanced glycation end products (AGE) in the pathogenesis of the disease. The first of the three sections investigates the structure of AGE-modified protein, its formation mechanisms and its biological activity. The book reveals that AGE-modified beta2-microglobulin has a chemotactic effect on monocytes, and stimulates macrophages to secrete interleuken 1beta, interleuken 6 and TNFalpha. In other sections, the factors causing dialysis related amyloidosis are examined and the effectiveness of various haemo-purification methods in alleviating osteoarthropathy are assessed.
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