Molecular biology in cancer medicine
著者
書誌事項
Molecular biology in cancer medicine
Dunitz, c1995
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Recent advances in molecular biology have led to the beginnings of an understanding of the molecular origins of malignancy. This understanding has practical relevance in the development of new screening methods in oncology. Methods such as oncogene amplification, gene rearrangement and aberrant receptor expression are now all used as markers of malignancy. It is hoped that this new understanding may soon be applied to the treatment of patients with malignancy. This book presents experimental and clinical developments in a way that is accessible for those involved in the treatment of malignant disease.
目次
- Polymerase chain reaction for the detection of minimal residual disease
- clinical uses and limitations of molecular methodologies
- fluorescent in situ hybridization - molecular cytogenetics
- clonogenic assays
- cytogenetics
- viruses and cancer
- oncogenes and tumour suppressor genes
- transcription factors and malignancy
- chronic myelogenous leukaemia
- molecular genetic defects in the myeloid leukaemias
- clinical implications of cytogenetic and molecular studies in chronic lymphoid leukaemias
- lymphomas
- molecular biology of T-cell lymphomas
- lung cancer
- breast cancer
- molecular genetic basis of colon cancer
- Wilm's tumours
- renal tumours
- ovarian cancer
- neuroblastoma
- melanoma
- endocrine tumours
- hereditary cancer syndromes
- acute promyelocytic leukaemia - implications of a defective retinoic acid receptor
- antisense and the inhibition of cancer genes
- gene therapy of cancer - current state of the art.
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