CiNii Books - Alternative mechanisms of multidrug resistance in cancer

Nullius in verba. . . Truth will be tested not by words. Horace (Epistles) Few read introductions except for book reviewers, who want to take a shortcut and avoid reading the book itself. However, tradition requires that the preface make public why the book was written at all (this is not supposed to include powerful reasons such as augmenting the ego of the editor and authors). Frequently, the inflationary tendency to publish in verbose length is in conflict with market forces and interest. No doubt, multidrug resistance is a "fashionable" topic, but there are many fashions displayed on the cat-walk of scientific literature. One can rationalize that the forces driving our concern with multi drug resistance reflect the frustration of pharmaceutical companies and oncologists alike: as soon as a new anticancer drug enters clinical trials, cancer cells start eluding extinction with their elaborate and successful mechanisms. Many grants have been awarded and spent, only to confirm the futility of our efforts to defeat this cellular Darwinism. Our medical and scientific training makes it hard, if not impossible, to accept that the survival of a malignant cell, alone or as part of a tissue, is part of the continuance of life. Since exposure to noxious and lethal substances is unavoidable, cells have been forced to develop a multitude of mechanisms to prevent entry or accelerate exit of such materials from intracellular space.

Table of Contents

1. Mechanisms of Multidrug Resistance.- 2. The Role of Glutathione S-Transferases in Drug Resistance.- 3. Pharmacology of Drug Transport in Multidrug Resistant Tumor Cells.- 4. The Multidrug Resistance-Associated Protein MRP.- 5. Topoisomerases in Multidrug Resistance.- 6. Genotoxicity of Topoisomerase II Inhibitors-Consequences of Chemotherapy.- 7. A Distinctive Multiple Drug Resistance Phenotype in Tumor Cells Exposed to X-Irradiation.- 8. Taxoids and Multidrug Resistance.- 9. The Contribution of Protein Kinase C to Multiple Drug Resistance in Cancer.- 10. Bcl-2 and Chemoresistance in Cancer.- 11. Molecular Interrelationships in Multidrug Resistance.- 12. Platinum Resistance in Human Carcinomas.- Perspectives.- Conclusions.

Volume: ISBN 9783764337759

Description

Drug resistance, whatever its source, is the prevalent cause for treatment failure in cancer chemotherapy. At present, the best understood (and most publicized) mechanism of cell resistance is the P-glycoprotein mediated efflux pump. However, it is not the only - or even the most effective - tool of survival devices to be considered in this book. Alterations of topoisomerases and conjugases, glutathione transferases, protein kinase C, the multidrug resistance protein MRP, bc12 and other modes of action are considered as well. By identifying and understanding how multidrug resistance in cancer evolves and functions, we should be able to prevent, circumvent or reverse this so far inescapable phenomenon. Featuring a collection of reviews by scientists, this book attempts to achieve an understanding of the molecular basis for drug resistance. It is intended for researchers in such diverse fields as chemotherapy, drug delivery, oncology, pathology, pharmacokinetics, tumour biology and biological response modifiers.

Table of Contents

Mechanisms of Multidrug Resistance, J.A. Kellen
The Role of Glutathione S-Transferases in Drug Resistance, W. T. Bellamy
Pharmacology of Drug Transport in Multidrug Resistant in Tumor Cells, H.J. Broxterman and C.H. Versantvoort
The Multidrug Resistance-Associated Protein MRP, D. Fan, D.R. Bielenberg, Y.F. Wang, R. Radinsky, and P.J. Beltran
Topoisomerases in Multidrug Resistance, T. Utsugi, C.E. Herzog, and D. Fan
Genotoxicity of Topoisomerases 11 Inhibitors-Consequences of Chemotherapy, F. Gieseler
A Distinctive Multiple Drug Resistance Phenotype in Tumor Cells Exposed to X-Irradiation, B. T. Hill
Taxoids and Multidrug Resistance, R.A.Newman and D. Fan
The Contribution of Protein Kinase C to Multiple Drug Resistance in Cancer, C.A. O'Brian, N.E. Ward, K.P. Gupta, and K.R. Gravitt
Bcl-2 and Chemoresistance in Cancer, J. C. Reed
Molecular Interrelationships in Multidrug Resistance, J.A. Kellen
Platinum Resistance in Human Carcinomas, H. Ishida, H. Kijima, Y. Ohta, M. Kashani-Sabet, and K.J. Scanlon.

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Alternative mechanisms of multidrug resistance in cancer

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